Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing

Hare, DJ; Faux, NG; Roberts, BR; Volitakis, I; Martins, RN; Bush, AI

Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing

Hare, DJ

Faux, NG Roberts, BR Volitakis, I Martins, RN Bush, AI

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Publication Type:: Journal Article
Citation:: Metallomics, 2016, 8 (6), pp. 628 - 632
Issue Date:: 2016-06-01

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Field	Value	Language
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Faux, NG	en_US
dc.contributor.author	Roberts, BR	en_US
dc.contributor.author	Volitakis, I	en_US
dc.contributor.author	Martins, RN	en_US
dc.contributor.author	Bush, AI	en_US
dc.date.issued	2016-06-01	en_US
dc.identifier.citation	Metallomics, 2016, 8 (6), pp. 628 - 632	en_US
dc.identifier.issn	1756-5901	en_US
dc.identifier.uri	http://hdl.handle.net/10453/42220
dc.description.abstract	© 2016 The Royal Society of Chemistry. We examined serum and erythrocyte lead and manganese levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), which contains over 1000 registrants including over 200 cases of Alzheimer's disease (AD) and 100 mildly cognitively impaired (MCI) individuals. After correcting for confounding effects of age, collection site and sex, we found a significant decrease in serum manganese levels in AD subjects compared to healthy controls. Analysis of smaller subset of erythrocytes revealed no difference in either lead or manganese levels in AD. Although lead and manganese have neurotoxic effects and may be involved in AD pathology, our results showed that neither metal in serum nor erythrocytes are suitable biomarkers in our cohort. However, prospective studies might reveal whether the burden of either metal modifies disease outcomes.	en_US
dc.relation.ispartof	Metallomics	en_US
dc.relation.isbasedon	10.1039/c6mt00019c	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Erythrocytes	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Alzheimer Disease	en_US
dc.subject.mesh	Lead	en_US
dc.subject.mesh	Manganese	en_US
dc.subject.mesh	Aging	en_US
dc.subject.mesh	Image Processing, Computer-Assisted	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Biomarkers	en_US
dc.subject.mesh	Cognitive Dysfunction	en_US
dc.title	Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: Results from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	8	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0302 Inorganic Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

© 2016 The Royal Society of Chemistry. We examined serum and erythrocyte lead and manganese levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), which contains over 1000 registrants including over 200 cases of Alzheimer's disease (AD) and 100 mildly cognitively impaired (MCI) individuals. After correcting for confounding effects of age, collection site and sex, we found a significant decrease in serum manganese levels in AD subjects compared to healthy controls. Analysis of smaller subset of erythrocytes revealed no difference in either lead or manganese levels in AD. Although lead and manganese have neurotoxic effects and may be involved in AD pathology, our results showed that neither metal in serum nor erythrocytes are suitable biomarkers in our cohort. However, prospective studies might reveal whether the burden of either metal modifies disease outcomes.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/42220