Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux

Lynch, EA; Langille, MGI; Darling, A; Wilbanks, EG; Haltiner, C; Shao, KSY; Starr, MO; Teiling, C; Harkins, TT; Edwards, RA; Eisen, JA; Facciotti, MT

Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux

Lynch, EA Langille, MGI Darling, A

Wilbanks, EG Haltiner, C Shao, KSY Starr, MO Teiling, C Harkins, TT Edwards, RA Eisen, JA Facciotti, MT

Permalink

Publication Type:: Journal Article
Citation:: PLoS ONE, 2012, 7 (7)
Issue Date:: 2012-07-24

Closed Access

	Filename	Description	Size
	2012004811OK.pdf		960.37 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Lynch, EA	en_US
dc.contributor.author	Langille, MGI	en_US
dc.contributor.author	Darling, A https://orcid.org/0000-0003-2397-7925	en_US
dc.contributor.author	Wilbanks, EG	en_US
dc.contributor.author	Haltiner, C	en_US
dc.contributor.author	Shao, KSY	en_US
dc.contributor.author	Starr, MO	en_US
dc.contributor.author	Teiling, C	en_US
dc.contributor.author	Harkins, TT	en_US
dc.contributor.author	Edwards, RA	en_US
dc.contributor.author	Eisen, JA	en_US
dc.contributor.author	Facciotti, MT	en_US
dc.date.available	2012-06-20	en_US
dc.date.issued	2012-07-24	en_US
dc.identifier.citation	PLoS ONE, 2012, 7 (7)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/43487
dc.description.abstract	We report the sequencing of seven genomes from two haloarchaeal genera, Haloferax and Haloarcula. Ease of cultivation and the existence of well-developed genetic and biochemical tools for several diverse haloarchaeal species make haloarchaea a model group for the study of archaeal biology. The unique physiological properties of these organisms also make them good candidates for novel enzyme discovery for biotechnological applications. Seven genomes were sequenced to ~20×coverage and assembled to an average of 50 contigs (range 5 scaffolds - 168 contigs). Comparisons of protein-coding gene compliments revealed large-scale differences in COG functional group enrichment between these genera. Analysis of genes encoding machinery for DNA metabolism reveals genera-specific expansions of the general transcription factor TATA binding protein as well as a history of extensive duplication and horizontal transfer of the proliferating cell nuclear antigen. Insights gained from this study emphasize the importance of haloarchaea for investigation of archaeal biology. © 2012 Lynch et al.	en_US
dc.relation.ispartof	PLoS ONE	en_US
dc.relation.isbasedon	10.1371/journal.pone.0041389	en_US
dc.subject.classification	General Science & Technology	en_US
dc.subject.mesh	Haloarcula	en_US
dc.subject.mesh	Haloferax	en_US
dc.subject.mesh	DNA, Archaeal	en_US
dc.subject.mesh	Sequence Analysis, DNA	en_US
dc.subject.mesh	Genome, Archaeal	en_US
dc.subject.mesh	Gene Flow	en_US
dc.title	Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.for	0604 Genetics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

We report the sequencing of seven genomes from two haloarchaeal genera, Haloferax and Haloarcula. Ease of cultivation and the existence of well-developed genetic and biochemical tools for several diverse haloarchaeal species make haloarchaea a model group for the study of archaeal biology. The unique physiological properties of these organisms also make them good candidates for novel enzyme discovery for biotechnological applications. Seven genomes were sequenced to ~20×coverage and assembled to an average of 50 contigs (range 5 scaffolds - 168 contigs). Comparisons of protein-coding gene compliments revealed large-scale differences in COG functional group enrichment between these genera. Analysis of genes encoding machinery for DNA metabolism reveals genera-specific expansions of the general transcription factor TATA binding protein as well as a history of extensive duplication and horizontal transfer of the proliferating cell nuclear antigen. Insights gained from this study emphasize the importance of haloarchaea for investigation of archaeal biology. © 2012 Lynch et al.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/23575