Metal ions in macrophage antimicrobial pathways: Emerging roles for zinc and copper

Stafford, SL; Bokil, NJ; Achard, MES; Kapetanovic, R; Schembri, MA; Mcewan, AG; Sweet, MJ

Metal ions in macrophage antimicrobial pathways: Emerging roles for zinc and copper

Stafford, SL Bokil, NJ

Achard, MES Kapetanovic, R Schembri, MA Mcewan, AG Sweet, MJ

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Publication Type:: Journal Article
Citation:: Bioscience Reports, 2013, 33 (4), pp. 541 - 554
Issue Date:: 2013-01-01

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Field	Value	Language
dc.contributor.author	Stafford, SL	en_US
dc.contributor.author	Bokil, NJ https://orcid.org/0000-0003-3202-9249	en_US
dc.contributor.author	Achard, MES	en_US
dc.contributor.author	Kapetanovic, R	en_US
dc.contributor.author	Schembri, MA	en_US
dc.contributor.author	Mcewan, AG	en_US
dc.contributor.author	Sweet, MJ	en_US
dc.date.issued	2013-01-01	en_US
dc.identifier.citation	Bioscience Reports, 2013, 33 (4), pp. 541 - 554	en_US
dc.identifier.issn	0144-8463	en_US
dc.identifier.uri	http://hdl.handle.net/10453/44118
dc.description.abstract	The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial growth and survival. This presents opportunities for the host to either harness their antimicrobial properties or limit their availability as defence strategies. Recent studies have shed some light on mechanisms by which copper and zinc regulation contribute to host defence, but there remain many unanswered questions at the cellular and molecular levels. Here we review the roles of these two metal ions in providing protection against infectious diseases in vivo, and in regulating innate immune responses. In particular, we focus on studies implicating zinc and copper in macrophage antimicrobial pathways, as well as the specific host genes encoding zinc transporters (SLC30A, SLC39A family members) and CTRs (copper transporters, ATP7 family members) that may contribute to pathogen control by these cells. © 2013 The Author(s).	en_US
dc.relation.ispartof	Bioscience Reports	en_US
dc.relation.isbasedon	10.1042/BSR20130014	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Macrophages	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Bacterial Infections	en_US
dc.subject.mesh	Copper	en_US
dc.subject.mesh	Zinc	en_US
dc.subject.mesh	Cation Transport Proteins	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.subject.mesh	Biological Transport	en_US
dc.subject.mesh	Dietary Supplements	en_US
dc.subject.mesh	Immunity, Innate	en_US
dc.title	Metal ions in macrophage antimicrobial pathways: Emerging roles for zinc and copper	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	33	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	33	en_US

Abstract:

The immunomodulatory and antimicrobial properties of zinc and copper have long been appreciated. In addition, these metal ions are also essential for microbial growth and survival. This presents opportunities for the host to either harness their antimicrobial properties or limit their availability as defence strategies. Recent studies have shed some light on mechanisms by which copper and zinc regulation contribute to host defence, but there remain many unanswered questions at the cellular and molecular levels. Here we review the roles of these two metal ions in providing protection against infectious diseases in vivo, and in regulating innate immune responses. In particular, we focus on studies implicating zinc and copper in macrophage antimicrobial pathways, as well as the specific host genes encoding zinc transporters (SLC30A, SLC39A family members) and CTRs (copper transporters, ATP7 family members) that may contribute to pathogen control by these cells. © 2013 The Author(s).

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http://hdl.handle.net/10453/44118