Urinary isoflavonoid excretion is inversely associated with the ratio of protein to dietary fibre intake in young women.

Blakesmith, SJ; Lyons-Wall, PM; Joannou, GE; Petocz, P; Samman, S

Urinary isoflavonoid excretion is inversely associated with the ratio of protein to dietary fibre intake in young women.

Blakesmith, SJ Lyons-Wall, PM Joannou, GE Petocz, P Samman, S

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Publication Type:: Journal Article
Citation:: Eur J Clin Nutr, 2005, 59 (2), pp. 284 - 290
Issue Date:: 2005-02

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Field	Value	Language
dc.contributor.author	Blakesmith, SJ	en_US
dc.contributor.author	Lyons-Wall, PM	en_US
dc.contributor.author	Joannou, GE	en_US
dc.contributor.author	Petocz, P	en_US
dc.contributor.author	Samman, S	en_US
dc.date.issued	2005-02	en_US
dc.identifier.citation	Eur J Clin Nutr, 2005, 59 (2), pp. 284 - 290	en_US
dc.identifier.issn	0954-3007	en_US
dc.identifier.uri	http://hdl.handle.net/10453/4484
dc.description.abstract	OBJECTIVE: To examine the prevalence of excretion of urinary isoflavonoids in women and determine any relationships with accustomed macronutrient intake. DESIGN: Volunteers in one of two 4-month studies. Study 1 was a randomised crossover study whereby subjects consumed a placebo or isoflavone supplement for 2 months and crossed over. Study 2 was a parallel design in which subjects consumed a placebo for 1 month and an isoflavone supplement for 3 months. SETTING: All subjects were free-living, healthy volunteers. SUBJECTS: A total of 25 (study 1, n=14; study 2, n=11) premenopausal women were recruited through advertisements. INTERVENTIONS: Volunteers were supplemented for 2 months (study 1) or 3 months (study 2) with purified isoflavones (86 mg/day) derived from red clover. Urinary isoflavonoids were measured during the placebo and the second month of isoflavone treatment. Macronutrient intakes were determined from weighed food records. RESULTS: During isoflavone supplementation, the concentration of urinary total isoflavonoids increased by 15-fold (P<0.0001), with 5.4-fold variation between individuals. Multiple linear regression analysis showed that 24% of this variation could be explained by an interaction between dietary fibre and protein (P=0.047), with a highly significant inverse association between total isoflavonoid concentration and the protein to fibre ratio (r=-0.51, P=0.009). CONCLUSIONS: Supplementation with purified isoflavones results in an increase in urinary isoflavonoid excretion and part of the individual variation in response is associated with an interaction between intakes of protein and dietary fibre. Whether manipulation of these macronutrients could enhance efficacy of isoflavone supplements remains to be determined.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Eur J Clin Nutr	en_US
dc.relation.isbasedon	10.1038/sj.ejcn.1602071	en_US
dc.subject.classification	Nutrition & Dietetics	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Trifolium	en_US
dc.subject.mesh	Isoflavones	en_US
dc.subject.mesh	Dietary Proteins	en_US
dc.subject.mesh	Biological Markers	en_US
dc.subject.mesh	Linear Models	en_US
dc.subject.mesh	Cross-Over Studies	en_US
dc.subject.mesh	Premenopause	en_US
dc.subject.mesh	Dietary Fiber	en_US
dc.subject.mesh	Dietary Supplements	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Biomarkers	en_US
dc.title	Urinary isoflavonoid excretion is inversely associated with the ratio of protein to dietary fibre intake in young women.	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	59	en_US
utslib.location.activity	England	en_US
utslib.for	1111 Nutrition and Dietetics	en_US
utslib.for	0908 Food Sciences	en_US
utslib.for	1106 Human Movement and Sports Sciences	en_US
dc.location.activity	Perth, WA
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	59	en_US

Abstract:

OBJECTIVE: To examine the prevalence of excretion of urinary isoflavonoids in women and determine any relationships with accustomed macronutrient intake. DESIGN: Volunteers in one of two 4-month studies. Study 1 was a randomised crossover study whereby subjects consumed a placebo or isoflavone supplement for 2 months and crossed over. Study 2 was a parallel design in which subjects consumed a placebo for 1 month and an isoflavone supplement for 3 months. SETTING: All subjects were free-living, healthy volunteers. SUBJECTS: A total of 25 (study 1, n=14; study 2, n=11) premenopausal women were recruited through advertisements. INTERVENTIONS: Volunteers were supplemented for 2 months (study 1) or 3 months (study 2) with purified isoflavones (86 mg/day) derived from red clover. Urinary isoflavonoids were measured during the placebo and the second month of isoflavone treatment. Macronutrient intakes were determined from weighed food records. RESULTS: During isoflavone supplementation, the concentration of urinary total isoflavonoids increased by 15-fold (P<0.0001), with 5.4-fold variation between individuals. Multiple linear regression analysis showed that 24% of this variation could be explained by an interaction between dietary fibre and protein (P=0.047), with a highly significant inverse association between total isoflavonoid concentration and the protein to fibre ratio (r=-0.51, P=0.009). CONCLUSIONS: Supplementation with purified isoflavones results in an increase in urinary isoflavonoid excretion and part of the individual variation in response is associated with an interaction between intakes of protein and dietary fibre. Whether manipulation of these macronutrients could enhance efficacy of isoflavone supplements remains to be determined.

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http://hdl.handle.net/10453/4484