Synthesis of alkaloid-like compounds via the bridging Ritter reactions II

Publication Type:
Journal Article
Monatshefte fur Chemie, 2016, 147 (10), pp. 1737 - 1746
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
art%3A10.1007%2Fs00706-016-1817-4.pdfPublished Version1.55 MB
Adobe PDF
© 2016, Springer-Verlag Wien. Abstract: The bridging Ritter reactions are considered to be efficient synthetic methods rapidly providing access to alkaloid-like compounds in a few steps from inexpensive starting materials. In this manuscript, we report the synthesis of benzo[c]azepine derivatives bearing either amide or hydroxyl groups via the bridging Ritter reactions. These compounds are diastereoisomers of a known AChE inhibitor. All the structures were fully characterised by NMR spectroscopy and high-resolution mass spectrometry. NMR spectral analysis of diastereoisomers has allowed for the relative stereochemistry of the AChE inhibitor to be established. Graphical abstract: [Figure not available: see fulltext.]
Please use this identifier to cite or link to this item: