Toxicity of, and development of predictive models for, substituted phenols to Ceridaphnia cf. dubia and Vibrio fischeri

Westbury, A; Warne, MS; Lim, RP

Toxicity of, and development of predictive models for, substituted phenols to Ceridaphnia cf. dubia and Vibrio fischeri

Westbury, A Warne, MS Lim, RP

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Publisher:: Australiasian Society for Ecotoxicology
Publication Type:: Journal Article
Citation:: Australasian Journal for Ecotoxicology, 2004, 10 (1), pp. 33 - 42
Issue Date:: 2004-01

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Field	Value	Language
dc.contributor.author	Westbury, A	en_US
dc.contributor.author	Warne, MS	en_US
dc.contributor.author	Lim, RP	en_US
dc.date.issued	2004-01	en_US
dc.identifier.citation	Australasian Journal for Ecotoxicology, 2004, 10 (1), pp. 33 - 42	en_US
dc.identifier.issn	1323-3475	en_US
dc.identifier.uri	http://hdl.handle.net/10453/6222
dc.description.abstract	Twelve substituted phenols that have a polar narcotic mode of action had their acute toxicity to the freshwater cladoceran Ceriodaphnia cf. dubia and the marine bacterium Vibrio fischeri determined. The 48-h EC50 (immobilisation) values of the chemicals to C. cf. dubia ranged from 6.13 to 183 Êmol/L while the 30-min EC50 (luminescence) values of the chemicals to V. fischeri ranged from 1.39 to 1031 Êmol/L. Seventy-five percent of the chemicals were classed as having moderate toxicity of to C. cf. dubia while 25 percent had below toxicity f. For V. fischeri the percentage of chemicals classified as having high moderate and below toxicity was approximately 17%, 33% and 50% respectively. Quantitative activity-activity relationships (QAARs) that could predict the toxicity of chemicals with a polar narcotic mode of action to C. cf. dubia were developed by regressing the toxicity data for polar narcotic chemicals to C. cf. dubia with that of eight non-Australasian species. Those QAARs based on the toxicity data for Tetrahymena pyriformis, Chlorella vulgaris, Poecilia reticulata and Daphnia magna were of high quality (r2 . 0.9). Only the QAARs for T. pyriformis, C. vulgaris and D. magna had sufficient data to test their validity. This revealed that the absolute percentage difference between experimentally derived EC50 values and those predicted by these QAARs were between 13 and 120%. These QAARs provide an easy, cost-effective means of estimating toxicity values for polar narcotic chemicals to C. cf. dubia.	en_US
dc.publisher	Australiasian Society for Ecotoxicology	en_US
dc.relation.ispartof	Australasian Journal for Ecotoxicology	en_US
dc.title	Toxicity of, and development of predictive models for, substituted phenols to Ceridaphnia cf. dubia and Vibrio fischeri	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	10	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	05 Environmental Sciences	en_US
utslib.for	06 Biological Sciences	en_US
dc.location.activity	Hyderabad, India
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.consider-herdc	true	en_US
pubs.issue	1	en_US
pubs.volume	10	en_US

Abstract:

Twelve substituted phenols that have a polar narcotic mode of action had their acute toxicity to the freshwater cladoceran Ceriodaphnia cf. dubia and the marine bacterium Vibrio fischeri determined. The 48-h EC50 (immobilisation) values of the chemicals to C. cf. dubia ranged from 6.13 to 183 Êmol/L while the 30-min EC50 (luminescence) values of the chemicals to V. fischeri ranged from 1.39 to 1031 Êmol/L. Seventy-five percent of the chemicals were classed as having moderate toxicity of to C. cf. dubia while 25 percent had below toxicity f. For V. fischeri the percentage of chemicals classified as having high moderate and below toxicity was approximately 17%, 33% and 50% respectively. Quantitative activity-activity relationships (QAARs) that could predict the toxicity of chemicals with a polar narcotic mode of action to C. cf. dubia were developed by regressing the toxicity data for polar narcotic chemicals to C. cf. dubia with that of eight non-Australasian species. Those QAARs based on the toxicity data for Tetrahymena pyriformis, Chlorella vulgaris, Poecilia reticulata and Daphnia magna were of high quality (r2 . 0.9). Only the QAARs for T. pyriformis, C. vulgaris and D. magna had sufficient data to test their validity. This revealed that the absolute percentage difference between experimentally derived EC50 values and those predicted by these QAARs were between 13 and 120%. These QAARs provide an easy, cost-effective means of estimating toxicity values for polar narcotic chemicals to C. cf. dubia.

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http://hdl.handle.net/10453/6222