Toxicity of, and development of predictive models for, substituted phenols to Ceridaphnia cf. dubia and Vibrio fischeri

Australiasian Society for Ecotoxicology
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Journal Article
Australasian Journal for Ecotoxicology, 2004, 10 (1), pp. 33 - 42
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Twelve substituted phenols that have a polar narcotic mode of action had their acute toxicity to the freshwater cladoceran Ceriodaphnia cf. dubia and the marine bacterium Vibrio fischeri determined. The 48-h EC50 (immobilisation) values of the chemicals to C. cf. dubia ranged from 6.13 to 183 Êmol/L while the 30-min EC50 (luminescence) values of the chemicals to V. fischeri ranged from 1.39 to 1031 Êmol/L. Seventy-five percent of the chemicals were classed as having moderate toxicity of to C. cf. dubia while 25 percent had below toxicity f. For V. fischeri the percentage of chemicals classified as having high moderate and below toxicity was approximately 17%, 33% and 50% respectively. Quantitative activity-activity relationships (QAARs) that could predict the toxicity of chemicals with a polar narcotic mode of action to C. cf. dubia were developed by regressing the toxicity data for polar narcotic chemicals to C. cf. dubia with that of eight non-Australasian species. Those QAARs based on the toxicity data for Tetrahymena pyriformis, Chlorella vulgaris, Poecilia reticulata and Daphnia magna were of high quality (r2 . 0.9). Only the QAARs for T. pyriformis, C. vulgaris and D. magna had sufficient data to test their validity. This revealed that the absolute percentage difference between experimentally derived EC50 values and those predicted by these QAARs were between 13 and 120%. These QAARs provide an easy, cost-effective means of estimating toxicity values for polar narcotic chemicals to C. cf. dubia.
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