Protein domains as units of genetic transfer

Chan, CX; Beiko, RG; Darling, AE; Ragan, MA

Protein domains as units of genetic transfer

Chan, CX Beiko, RG Darling, AE

Ragan, MA

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Field	Value	Language
dc.contributor.author	Chan, CX	en_US
dc.contributor.author	Beiko, RG	en_US
dc.contributor.author	Darling, AE https://orcid.org/0000-0003-2397-7925	en_US
dc.contributor.author	Ragan, MA	en_US
dc.identifier.uri	http://hdl.handle.net/10453/65030
dc.description.abstract	Genomes evolve as modules. In prokaryotes (and some eukaryotes), genetic material can be transferred between species and integrated into the genome via homologous or illegitimate recombination. There is little reason to imagine that the units of transfer correspond to entire genes; however, such units have not been rigorously characterized. We examined fragmentary genetic transfers in single-copy gene families from 144 prokaryotic genomes and found that breakpoints are located significantly closer to the boundaries of genomic regions that encode annotated structural domains of proteins than expected by chance, particularly when recombining sequences are more divergent. This correlation results from recombination events themselves and not from differential nucleotide substitution. We report the first systematic study relating genetic recombination to structural features at the protein level.	en_US
dc.title	Protein domains as units of genetic transfer	en_US
dc.type	Journal Article
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access

Abstract:

Genomes evolve as modules. In prokaryotes (and some eukaryotes), genetic material can be transferred between species and integrated into the genome via homologous or illegitimate recombination. There is little reason to imagine that the units of transfer correspond to entire genes; however, such units have not been rigorously characterized. We examined fragmentary genetic transfers in single-copy gene families from 144 prokaryotic genomes and found that breakpoints are located significantly closer to the boundaries of genomic regions that encode annotated structural domains of proteins than expected by chance, particularly when recombining sequences are more divergent. This correlation results from recombination events themselves and not from differential nucleotide substitution. We report the first systematic study relating genetic recombination to structural features at the protein level.

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http://hdl.handle.net/10453/65030