Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

Bos, KI; Herbig, A; Sahl, J; Waglechner, N; Fourment, M; Forrest, SA; Klunk, J; Schuenemann, VJ; Poinar, D; Kuch, M; Golding, GB; Dutour, O; Keim, P; Wagner, DM; Holmes, EC; Krause, J; Poinar, HN

Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

Bos, KI Herbig, A Sahl, J Waglechner, N Fourment, M

Forrest, SA Klunk, J Schuenemann, VJ Poinar, D Kuch, M Golding, GB Dutour, O Keim, P Wagner, DM Holmes, EC Krause, J Poinar, HN

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Publication Type:: Journal Article
Citation:: eLife, 2016, 5 (JANUARY2016)
Issue Date:: 2016-01-21

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Field	Value	Language
dc.contributor.author	Bos, KI	en_US
dc.contributor.author	Herbig, A	en_US
dc.contributor.author	Sahl, J	en_US
dc.contributor.author	Waglechner, N	en_US
dc.contributor.author	Fourment, M https://orcid.org/0000-0001-8153-9822	en_US
dc.contributor.author	Forrest, SA	en_US
dc.contributor.author	Klunk, J	en_US
dc.contributor.author	Schuenemann, VJ	en_US
dc.contributor.author	Poinar, D	en_US
dc.contributor.author	Kuch, M	en_US
dc.contributor.author	Golding, GB	en_US
dc.contributor.author	Dutour, O	en_US
dc.contributor.author	Keim, P	en_US
dc.contributor.author	Wagner, DM	en_US
dc.contributor.author	Holmes, EC	en_US
dc.contributor.author	Krause, J	en_US
dc.contributor.author	Poinar, HN	en_US
dc.date.available	2016-01-19	en_US
dc.date.issued	2016-01-21	en_US
dc.identifier.citation	eLife, 2016, 5 (JANUARY2016)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/65279
dc.description.abstract	© Bos et al. The 14th-18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague's persistence and abrupt disappearance in Europe are poorly understood, but could have been due to either the presence of now-extinct plague foci in Europe itself, or successive disease introductions from other locations. Here we present five Y. pestis genomes from one of the last European outbreaks of plague, from 1722 in Marseille, France. The lineage identified has not been found in any extant Y. pestis foci sampled to date, and has its ancestry in strains obtained from victims of the 14th century Black Death. These data suggest the existence of a previously uncharacterized historical plague focus that persisted for at least three centuries. We propose that this disease source may have been responsible for the many resurgences of plague in Europe following the Black Death.	en_US
dc.relation.ispartof	eLife	en_US
dc.relation.isbasedon	10.7554/eLife.12994.001	en_US
dc.subject.mesh	Yersinia pestis	en_US
dc.subject.mesh	Plague	en_US
dc.subject.mesh	Genotype	en_US
dc.subject.mesh	Genome, Bacterial	en_US
dc.subject.mesh	History, 15th Century	en_US
dc.subject.mesh	History, 16th Century	en_US
dc.subject.mesh	History, 17th Century	en_US
dc.subject.mesh	History, 18th Century	en_US
dc.subject.mesh	Europe	en_US
dc.subject.mesh	Molecular Epidemiology	en_US
dc.title	Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus	en_US
dc.type	Journal Article
utslib.citation.volume	JANUARY2016	en_US
utslib.citation.volume	5	en_US
utslib.for	060506 Virology	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	JANUARY2016	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

© Bos et al. The 14th-18th century pandemic of Yersinia pestis caused devastating disease outbreaks in Europe for almost 400 years. The reasons for plague's persistence and abrupt disappearance in Europe are poorly understood, but could have been due to either the presence of now-extinct plague foci in Europe itself, or successive disease introductions from other locations. Here we present five Y. pestis genomes from one of the last European outbreaks of plague, from 1722 in Marseille, France. The lineage identified has not been found in any extant Y. pestis foci sampled to date, and has its ancestry in strains obtained from victims of the 14th century Black Death. These data suggest the existence of a previously uncharacterized historical plague focus that persisted for at least three centuries. We propose that this disease source may have been responsible for the many resurgences of plague in Europe following the Black Death.

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http://hdl.handle.net/10453/65279