Long-term Follow-up Study of Fecal Microbiota Transplantation for Severe and/or Complicated Clostridium difficile Infection: A Multicenter Experience.

Aroniadis, OC; Brandt, LJ; Greenberg, A; Borody, T; Kelly, CR; Mellow, M; Surawicz, C; Cagle, L; Neshatian, L; Stollman, N; Giovanelli, A; Ray, A; Smith, R

Long-term Follow-up Study of Fecal Microbiota Transplantation for Severe and/or Complicated Clostridium difficile Infection: A Multicenter Experience.

Aroniadis, OC Brandt, LJ Greenberg, A Borody, T

Kelly, CR Mellow, M Surawicz, C Cagle, L Neshatian, L Stollman, N Giovanelli, A Ray, A Smith, R

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Publication Type:: Journal Article
Citation:: J Clin Gastroenterol, 2016, 50 (5), pp. 398 - 402
Issue Date:: 2016-05

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Field	Value	Language
dc.contributor.author	Aroniadis, OC	en_US
dc.contributor.author	Brandt, LJ	en_US
dc.contributor.author	Greenberg, A	en_US
dc.contributor.author	Borody, T https://orcid.org/0000-0002-0519-4698	en_US
dc.contributor.author	Kelly, CR	en_US
dc.contributor.author	Mellow, M	en_US
dc.contributor.author	Surawicz, C	en_US
dc.contributor.author	Cagle, L	en_US
dc.contributor.author	Neshatian, L	en_US
dc.contributor.author	Stollman, N	en_US
dc.contributor.author	Giovanelli, A	en_US
dc.contributor.author	Ray, A	en_US
dc.contributor.author	Smith, R	en_US
dc.date.issued	2016-05	en_US
dc.identifier.citation	J Clin Gastroenterol, 2016, 50 (5), pp. 398 - 402	en_US
dc.identifier.uri	http://hdl.handle.net/10453/75037
dc.description.abstract	GOAL: Our aim was to investigate fecal microbiota transplantation (FMT) efficacy in patients with severe and/or complicated Clostridium difficile infection (CDI). BACKGROUND: FMT is successful for recurrent CDI, although its benefit in severe or complicated CDI has not specifically been evaluated. STUDY METHODS: A multicenter long-term follow-up study was performed in patients who received FMT for severe and/or complicated CDI (diagnosed using standard criteria). Pre-FMT and post-FMT questionnaires were completed. Study outcomes included cure rates and time to resolution of symptoms. RESULTS: A total of 17 patients (82% inpatients, 18% outpatients) were included (76.4% women; mean age, 66.4 y; mean follow-up, 11.4 mo). Patients had severe and complicated (76.4%) or either severe or complicated (23.6%) CDI. Sixteen patients (94.1%) had diarrhea, which resolved in 12 (75%; mean time to resolution, 5.7 d) and improved in 4 (25%) after FMT. Eleven patients (64.7%) had abdominal pain, which resolved in 8 (72.7%; mean time to resolution, 9.6 d) and improved in 3 (27.3%) after FMT. Two of 17 patients experienced early CDI recurrence (≤90 d) after FMT (primary cure rate, 88.2%); and in 1 patient, a second FMT resulted in cure (secondary cure rate, 94.1%). Late CDI recurrence (≥90 d) was seen in 1 of 17 patients (5.9%) in association with antibiotics and was successfully treated with a repeat FMT. No adverse effects directly related to FMT occurred. CONCLUSIONS: FMT was successful and safe in this cohort of patients with severe or complicated CDI. Primary and secondary cure rates were 88.2% and 94.1%, respectively.	en_US
dc.language	eng	en_US
dc.relation.ispartof	J Clin Gastroenterol	en_US
dc.relation.isbasedon	10.1097/MCG.0000000000000374	en_US
dc.subject.classification	Gastroenterology & Hepatology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Clostridium difficile	en_US
dc.subject.mesh	Clostridium Infections	en_US
dc.subject.mesh	Recurrence	en_US
dc.subject.mesh	Abdominal Pain	en_US
dc.subject.mesh	Diarrhea	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Treatment Outcome	en_US
dc.subject.mesh	Severity of Illness Index	en_US
dc.subject.mesh	Retrospective Studies	en_US
dc.subject.mesh	Follow-Up Studies	en_US
dc.subject.mesh	Time Factors	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Aged	en_US
dc.subject.mesh	Aged, 80 and over	en_US
dc.subject.mesh	Middle Aged	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Surveys and Questionnaires	en_US
dc.subject.mesh	Fecal Microbiota Transplantation	en_US
dc.title	Long-term Follow-up Study of Fecal Microbiota Transplantation for Severe and/or Complicated Clostridium difficile Infection: A Multicenter Experience.	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	50	en_US
utslib.location.activity	United States	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	50	en_US

Abstract:

GOAL: Our aim was to investigate fecal microbiota transplantation (FMT) efficacy in patients with severe and/or complicated Clostridium difficile infection (CDI). BACKGROUND: FMT is successful for recurrent CDI, although its benefit in severe or complicated CDI has not specifically been evaluated. STUDY METHODS: A multicenter long-term follow-up study was performed in patients who received FMT for severe and/or complicated CDI (diagnosed using standard criteria). Pre-FMT and post-FMT questionnaires were completed. Study outcomes included cure rates and time to resolution of symptoms. RESULTS: A total of 17 patients (82% inpatients, 18% outpatients) were included (76.4% women; mean age, 66.4 y; mean follow-up, 11.4 mo). Patients had severe and complicated (76.4%) or either severe or complicated (23.6%) CDI. Sixteen patients (94.1%) had diarrhea, which resolved in 12 (75%; mean time to resolution, 5.7 d) and improved in 4 (25%) after FMT. Eleven patients (64.7%) had abdominal pain, which resolved in 8 (72.7%; mean time to resolution, 9.6 d) and improved in 3 (27.3%) after FMT. Two of 17 patients experienced early CDI recurrence (≤90 d) after FMT (primary cure rate, 88.2%); and in 1 patient, a second FMT resulted in cure (secondary cure rate, 94.1%). Late CDI recurrence (≥90 d) was seen in 1 of 17 patients (5.9%) in association with antibiotics and was successfully treated with a repeat FMT. No adverse effects directly related to FMT occurred. CONCLUSIONS: FMT was successful and safe in this cohort of patients with severe or complicated CDI. Primary and secondary cure rates were 88.2% and 94.1%, respectively.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/75037