Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats.

Li, Y; Peng, G; Li, Q; Wen, S; Huang, TH-W; Roufogalis, BD; Yamahara, J

Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats.

Li, Y Peng, G Li, Q Wen, S Huang, TH-W Roufogalis, BD Yamahara, J

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Publication Type:: Journal Article
Citation:: Life Sci, 2004, 75 (14), pp. 1735 - 1746
Issue Date:: 2004-08-20

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Field	Value	Language
dc.contributor.author	Li, Y	en_US
dc.contributor.author	Peng, G	en_US
dc.contributor.author	Li, Q	en_US
dc.contributor.author	Wen, S	en_US
dc.contributor.author	Huang, TH-W	en_US
dc.contributor.author	Roufogalis, BD	en_US
dc.contributor.author	Yamahara, J	en_US
dc.date.available	2004-04-07	en_US
dc.date.issued	2004-08-20	en_US
dc.identifier.citation	Life Sci, 2004, 75 (14), pp. 1735 - 1746	en_US
dc.identifier.issn	0024-3205	en_US
dc.identifier.uri	http://hdl.handle.net/10453/810
dc.description.abstract	Diabetes has a markedly greater incidence of cardiovascular disease than the non-diabetic population. The heart shows a slowly developing increase in fibrosis in diabetes. Extended cardiac fibrosis results in increased myocardial stiffness, causing ventricular dysfunction and, ultimately, heart failure. Reversal of fibrosis may improve organ function survival. Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and cardiovascular complications, and has been proposed as an independent risk factor for cardiovascular diseases. Salacia oblonga (S.O.) is traditionally used in the prevention and treatment of diabetes. We investigated the effects of its water extract on cardiac fibrosis and hyperglycemia in a genetic model of type 2 diabetes, the obese Zucker rat (OZR). Chronic administration of the extract markedly improved interstitial and perivascular fibrosis in the hearts of the OZR. It also reduced plasma glucose levels in non-fasted OZR, whereas it had little effect in the fasted animals, suggesting inhibition of postprandial hyperglycemia in type 2 diabetic animals, which might play a role in improvement of the cardiac complications of OZR. Furthermore, S.O. markedly suppressed the overexpression of mRNAs encoding transforming growth factor betas 1 and 3 in the OZR heart, which may be an important part of the overall molecular mechanisms. S.O. dose-dependently inhibited the increase of plasma glucose in sucrose-, but not in glucose-loaded mice. S.O. demonstrated a strong inhibition of alpha-glucosidase activity in vitro, which is suggested to contribute to the improvement of postprandial hyperglycemia.	en_US
dc.language	eng	en_US
dc.relation.ispartof	Life Sci	en_US
dc.relation.isbasedon	10.1016/j.lfs.2004.04.013	en_US
dc.subject.classification	Pharmacology & Pharmacy	en_US
dc.subject.mesh	Heart Ventricles	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Rats, Zucker	en_US
dc.subject.mesh	Celastraceae	en_US
dc.subject.mesh	Endomyocardial Fibrosis	en_US
dc.subject.mesh	Hypoglycemia	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Xanthones	en_US
dc.subject.mesh	alpha-Glucosidases	en_US
dc.subject.mesh	Blood Glucose	en_US
dc.subject.mesh	Transforming Growth Factor beta	en_US
dc.subject.mesh	RNA, Messenger	en_US
dc.subject.mesh	DNA Primers	en_US
dc.subject.mesh	Plant Extracts	en_US
dc.subject.mesh	Chromatography, High Pressure Liquid	en_US
dc.subject.mesh	Histological Techniques	en_US
dc.subject.mesh	Analysis of Variance	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.subject.mesh	Male	en_US
dc.title	Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats.	en_US
dc.type	Journal Article
utslib.citation.volume	14	en_US
utslib.citation.volume	75	en_US
utslib.location.activity	Netherlands	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.issue	14	en_US
pubs.publication-status	Published	en_US
pubs.volume	75	en_US

Abstract:

Diabetes has a markedly greater incidence of cardiovascular disease than the non-diabetic population. The heart shows a slowly developing increase in fibrosis in diabetes. Extended cardiac fibrosis results in increased myocardial stiffness, causing ventricular dysfunction and, ultimately, heart failure. Reversal of fibrosis may improve organ function survival. Postprandial hyperglycemia plays an important role in the development of type 2 diabetes and cardiovascular complications, and has been proposed as an independent risk factor for cardiovascular diseases. Salacia oblonga (S.O.) is traditionally used in the prevention and treatment of diabetes. We investigated the effects of its water extract on cardiac fibrosis and hyperglycemia in a genetic model of type 2 diabetes, the obese Zucker rat (OZR). Chronic administration of the extract markedly improved interstitial and perivascular fibrosis in the hearts of the OZR. It also reduced plasma glucose levels in non-fasted OZR, whereas it had little effect in the fasted animals, suggesting inhibition of postprandial hyperglycemia in type 2 diabetic animals, which might play a role in improvement of the cardiac complications of OZR. Furthermore, S.O. markedly suppressed the overexpression of mRNAs encoding transforming growth factor betas 1 and 3 in the OZR heart, which may be an important part of the overall molecular mechanisms. S.O. dose-dependently inhibited the increase of plasma glucose in sucrose-, but not in glucose-loaded mice. S.O. demonstrated a strong inhibition of alpha-glucosidase activity in vitro, which is suggested to contribute to the improvement of postprandial hyperglycemia.

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http://hdl.handle.net/10453/810