Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase

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Journal Article
Life Sciences, 2006, 78 (9), pp. 995 - 1002
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Ileus continues to be a common consequence of abdominal surgery, causing significant patient discomfort and often leading to more serious problems. The therapy available is limited, hence, ileus remains an important clinical problem. Activation of inducible nitric oxide synthase (iNOS) directly modulates intestinal dysmotility after bowel manipulation and plays an essential role in initiating intestinal inflammation. Nuclear factor (NF) kB i sknown to be a critical component of iNOS gene transcriptional activation in response to inflammatory stimuli. Bromlain is an crude extract from the pineapply stem, which is sold as a nutritional supplement to promote digestive health and as an anti-inflammatory medication in some developed countries. Here we have found that oral administration of bromelain improves decrease in defecation in abdominal postoperative rats. Results showed that bromelain increased wet weight, dry weight, water content and number of fecal pellets in laparotomised plus mechanically manipulated rats, suggetsing imporvement of postoperative ileus.
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