Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues
- Publication Type:
- Journal Article
- Citation:
- Tetrahedron, 2005, 61 (7), pp. 1803 - 1812
- Issue Date:
- 2005-02-14
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The conformationally restricted glutamate analogues, 4-aryl-1-amino-2- cyclopentene-1,3-dicarboxylates and their cyclopentane analogues have been prepared in a diastereoselective manner. Biological studies of 12a and 12b indicates that both compounds are modest antagonists at mGluR2. © 2004 Elsevier Ltd. All rights reserved.
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