A synthetically simple, click-generated cyclam-based zinc(ll) sensor

Publication Type:
Journal Article
Inorganic Chemistry, 2009, 48 (1), pp. 319 - 324
Issue Date:
Filename Description Size
Thumbnail2008007905OK.pdf273.33 kB
Adobe PDF
Full metadata record
A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death. © 2009 American Chemical Society.
Please use this identifier to cite or link to this item: