A synthetically simple, click-generated cyclam-based zinc(ll) sensor

Publication Type:
Journal Article
Citation:
Inorganic Chemistry, 2009, 48 (1), pp. 319 - 324
Issue Date:
2009-01-05
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A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death. © 2009 American Chemical Society.
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