A Synthetically Simple, Click-Generated Cyclam-Based Zinc(II) Sensor

Amer Chemical Soc
Publication Type:
Journal Article
Inorganic Chemistry, 2009, 48 (1), pp. 319 - 324
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2008007905OK.pdf273.33 kB
Adobe PDF
A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(II) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(II) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle, The sensor can access biologically available zinc in mammalian cells, sensing the Zn(II) flux that exists during apoptotic cell death.
Please use this identifier to cite or link to this item: