A synthetically simple, click-generated cyclam-based zinc(ll) sensor

Tamanini, E; Katewa, A; Sedger, LM; Todd, MH; Watkinson, M

A synthetically simple, click-generated cyclam-based zinc(ll) sensor

Tamanini, E Katewa, A Sedger, LM

Todd, MH Watkinson, M

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Publication Type:: Journal Article
Citation:: Inorganic Chemistry, 2009, 48 (1), pp. 319 - 324
Issue Date:: 2009-01-05

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Field	Value	Language
dc.contributor.author	Tamanini, E	en_US
dc.contributor.author	Katewa, A	en_US
dc.contributor.author	Sedger, LM https://orcid.org/0000-0003-1009-5683	en_US
dc.contributor.author	Todd, MH	en_US
dc.contributor.author	Watkinson, M	en_US
dc.date.issued	2009-01-05	en_US
dc.identifier.citation	Inorganic Chemistry, 2009, 48 (1), pp. 319 - 324	en_US
dc.identifier.issn	0020-1669	en_US
dc.identifier.uri	http://hdl.handle.net/10453/8461
dc.description.abstract	A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death. © 2009 American Chemical Society.	en_US
dc.relation.ispartof	Inorganic Chemistry	en_US
dc.relation.isbasedon	10.1021/ic8017634	en_US
dc.subject.classification	Inorganic & Nuclear Chemistry	en_US
dc.subject.mesh	Cell Line	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Zinc	en_US
dc.subject.mesh	Heterocyclic Compounds	en_US
dc.subject.mesh	Triazoles	en_US
dc.subject.mesh	Carbonic Anhydrases	en_US
dc.subject.mesh	Fluorescent Dyes	en_US
dc.subject.mesh	Binding, Competitive	en_US
dc.subject.mesh	Electron Transport	en_US
dc.subject.mesh	Light	en_US
dc.subject.mesh	Fluorescence	en_US
dc.title	A synthetically simple, click-generated cyclam-based zinc(ll) sensor	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	48	en_US
utslib.for	0302 Inorganic Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
dc.location.activity	ISI:000262011700040	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	48	en_US

Abstract:

A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death. © 2009 American Chemical Society.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/8461