M-T2: A poxvirus TNF receptor homologue with dual activities

Sedger, L; McFadden, G

M-T2: A poxvirus TNF receptor homologue with dual activities

Sedger, L

McFadden, G

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Publication Type:: Journal Article
Citation:: Immunology and Cell Biology, 1996, 74 (6), pp. 538 - 545
Issue Date:: 1996-01-01

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Field	Value	Language
dc.contributor.author	Sedger, L https://orcid.org/0000-0003-1009-5683	en_US
dc.contributor.author	McFadden, G	en_US
dc.date.issued	1996-01-01	en_US
dc.identifier.citation	Immunology and Cell Biology, 1996, 74 (6), pp. 538 - 545	en_US
dc.identifier.issn	0818-9641	en_US
dc.identifier.uri	http://hdl.handle.net/10453/8607
dc.description.abstract	Poxviruses are experts at manipulating and evading the host's immune response. They have acquired a number of open reading frames which specifically confer direct anti-immune properties, either by mimicking cytokine receptors and growth factors or by disarming cytokine regulatory cascades. The Myxoma T2 protein (M-T2), a TNF receptor homologue, is secreted from virus infected cells and can bind TNF-α with high affinity, and thereby inhibit TNF-α-mediated cytotoxicity. M-T2 also acts to inhibit virus-induced lymphocyte apoptosis by an as yet undefined mechanism. As such, T2 constitutes a significant virulence factor for poxviruses, influencing the outcome of infection, both in vitro and in vivo.	en_US
dc.relation.ispartof	Immunology and Cell Biology	en_US
dc.relation.isbasedon	10.1038/icb.1996.87	en_US
dc.subject.classification	Immunology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Poxviridae	en_US
dc.subject.mesh	Receptors, Tumor Necrosis Factor	en_US
dc.subject.mesh	Viral Proteins	en_US
dc.title	M-T2: A poxvirus TNF receptor homologue with dual activities	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	74	en_US
utslib.for	060103 Cell Development, Proliferation and Death	en_US
utslib.for	060506 Virology	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1107 Immunology	en_US
dc.location.activity	ISI:A1996VV26200008	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	74	en_US

Abstract:

Poxviruses are experts at manipulating and evading the host's immune response. They have acquired a number of open reading frames which specifically confer direct anti-immune properties, either by mimicking cytokine receptors and growth factors or by disarming cytokine regulatory cascades. The Myxoma T2 protein (M-T2), a TNF receptor homologue, is secreted from virus infected cells and can bind TNF-α with high affinity, and thereby inhibit TNF-α-mediated cytotoxicity. M-T2 also acts to inhibit virus-induced lymphocyte apoptosis by an as yet undefined mechanism. As such, T2 constitutes a significant virulence factor for poxviruses, influencing the outcome of infection, both in vitro and in vivo.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/8607