Bacterial cell division: Regulating Z-ring formation

Harry, EJ

Bacterial cell division: Regulating Z-ring formation

Harry, EJ

Permalink

Publication Type:: Journal Article
Citation:: Molecular Microbiology, 2001, 40 (4), pp. 795 - 803
Issue Date:: 2001-06-21

Closed Access

	Filename	Description	Size
	2006008256OK.pdf		2.18 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Harry, EJ https://orcid.org/0000-0003-0858-9473	en_US
dc.date.issued	2001-06-21	en_US
dc.identifier.citation	Molecular Microbiology, 2001, 40 (4), pp. 795 - 803	en_US
dc.identifier.issn	0950-382X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/8699
dc.description.abstract	The earliest stage of cell division in bacteria is the formation of a Z ring, composed of a polymer of the FtsZ protein, at the division site. Z rings appear to be synthesized in a bi-directional manner from a nucleation site (NS) located on the inside of the cytoplasmic membrane. It is the utilization of a NS specifically at the site of septum formation that determines where and when division will occur. However, a Z ring can be made to form at positions other than at the division site. How does a cell regulate utilization of a NS at the correct location and at the right time? In rod-shaped bacteria such as Escherichia coli and Bacillus subtilis, two factors involved in this regulation are the Min system and nucleoid occlusion. It is suggested that in B. subtilis, the main role of the Min proteins is to inhibit division at the nucleoid-free cell poles. In E. coli it is currently not clear whether the Min system can direct a Z ring to the division site at mid-cell or whether its main role is to ensure that division inhibition occurs away from mid-cell, a role analogous to that in B. subtilis. While the nucleoid negatively influences Z-ring formation in its vicinity in these rod-shaped organisms, the exact relationship between nucleoid occlusion and the ability to form a mid-cell Z ring is unresolved. Recent evidence suggests that in B. subtilis and Caulobacter crescentus, utilization of the NS at the division site is intimately linked to the progress of a round of chromosome replication and this may form the basis of achieving co-ordination between chromosome replication and cell division.	en_US
dc.relation.ispartof	Molecular Microbiology	en_US
dc.relation.isbasedon	10.1046/j.1365-2958.2001.02370.x	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Cellular Structures	en_US
dc.subject.mesh	Chromosomes, Bacterial	en_US
dc.subject.mesh	Bacteria	en_US
dc.subject.mesh	Bacillus subtilis	en_US
dc.subject.mesh	Escherichia coli	en_US
dc.subject.mesh	Bacterial Proteins	en_US
dc.subject.mesh	Cytoskeletal Proteins	en_US
dc.subject.mesh	Cell Division	en_US
dc.subject.mesh	DNA Replication	en_US
dc.subject.mesh	Operon	en_US
dc.title	Bacterial cell division: Regulating Z-ring formation	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	40	en_US
utslib.for	110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)	en_US
utslib.for	060504 Microbial Ecology	en_US
utslib.for	060501 Bacteriology	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	07 Agricultural and Veterinary Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	40	en_US

Abstract:

The earliest stage of cell division in bacteria is the formation of a Z ring, composed of a polymer of the FtsZ protein, at the division site. Z rings appear to be synthesized in a bi-directional manner from a nucleation site (NS) located on the inside of the cytoplasmic membrane. It is the utilization of a NS specifically at the site of septum formation that determines where and when division will occur. However, a Z ring can be made to form at positions other than at the division site. How does a cell regulate utilization of a NS at the correct location and at the right time? In rod-shaped bacteria such as Escherichia coli and Bacillus subtilis, two factors involved in this regulation are the Min system and nucleoid occlusion. It is suggested that in B. subtilis, the main role of the Min proteins is to inhibit division at the nucleoid-free cell poles. In E. coli it is currently not clear whether the Min system can direct a Z ring to the division site at mid-cell or whether its main role is to ensure that division inhibition occurs away from mid-cell, a role analogous to that in B. subtilis. While the nucleoid negatively influences Z-ring formation in its vicinity in these rod-shaped organisms, the exact relationship between nucleoid occlusion and the ability to form a mid-cell Z ring is unresolved. Recent evidence suggests that in B. subtilis and Caulobacter crescentus, utilization of the NS at the division site is intimately linked to the progress of a round of chromosome replication and this may form the basis of achieving co-ordination between chromosome replication and cell division.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/8699