Dientamoeba fragilis, the neglected trichomonad of the human bowel

Stark, D; Barratt, J; Chan, D; Ellis, JT

Dientamoeba fragilis, the neglected trichomonad of the human bowel

Stark, D Barratt, J

Chan, D Ellis, JT

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Publication Type:: Journal Article
Citation:: Clinical Microbiology Reviews, 2016, 29 (3), pp. 553 - 580
Issue Date:: 2016-07-01

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Field	Value	Language
dc.contributor.author	Stark, D	en_US
dc.contributor.author	Barratt, J https://orcid.org/0000-0001-8711-2408	en_US
dc.contributor.author	Chan, D	en_US
dc.contributor.author	Ellis, JT https://orcid.org/0000-0001-7328-4831	en_US
dc.date.issued	2016-07-01	en_US
dc.identifier.citation	Clinical Microbiology Reviews, 2016, 29 (3), pp. 553 - 580	en_US
dc.identifier.issn	0893-8512	en_US
dc.identifier.uri	http://hdl.handle.net/10453/87542
dc.description.abstract	© 2016, American Society for Microbiology. All Rights Reserved. Dientamoeba fragilis is a protozoan parasite of the human bowel, commonly reported throughout the world in association with gastrointestinal symptoms. Despite its initial discovery over 100 years ago, arguably, we know less about this peculiar organism than any other pathogenic or potentially pathogenic protozoan that infects humans. The details of its life cycle and mode of transmission are not completely known, and its potential as a human pathogen is debated within the scientific community. Recently, several major advances have been made with respect to this organism’s life cycle and molecular biology. While many questions remain unanswered, these and other recent advances have given rise to some intriguing new leads, which will pave the way for future research. This review encompasses a large body of knowledge generated on various aspects of D. fragilis over the last century, together with an update on the most recent developments. This includes an update on the latest diagnostic techniques and treatments, the clinical aspects of dientamoebiasis, the development of an animal model, the description of a D. fragilis cyst stage, and the sequencing of the first D. fragilis transcriptome.	en_US
dc.relation.ispartof	Clinical Microbiology Reviews	en_US
dc.relation.isbasedon	10.1128/CMR.00076-15	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Intestines	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Dientamoeba	en_US
dc.subject.mesh	Dientamoebiasis	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Life Cycle Stages	en_US
dc.title	Dientamoeba fragilis, the neglected trichomonad of the human bowel	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	29	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	110303 Clinical Microbiology	en_US
utslib.for	07 Agricultural and Veterinary Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	29	en_US

Abstract:

© 2016, American Society for Microbiology. All Rights Reserved. Dientamoeba fragilis is a protozoan parasite of the human bowel, commonly reported throughout the world in association with gastrointestinal symptoms. Despite its initial discovery over 100 years ago, arguably, we know less about this peculiar organism than any other pathogenic or potentially pathogenic protozoan that infects humans. The details of its life cycle and mode of transmission are not completely known, and its potential as a human pathogen is debated within the scientific community. Recently, several major advances have been made with respect to this organism’s life cycle and molecular biology. While many questions remain unanswered, these and other recent advances have given rise to some intriguing new leads, which will pave the way for future research. This review encompasses a large body of knowledge generated on various aspects of D. fragilis over the last century, together with an update on the most recent developments. This includes an update on the latest diagnostic techniques and treatments, the clinical aspects of dientamoebiasis, the development of an animal model, the description of a D. fragilis cyst stage, and the sequencing of the first D. fragilis transcriptome.

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http://hdl.handle.net/10453/87542