Engineering thick tissues - The vascularisation problem

Ko, HCH; Milthorpe, BK; McFarland, CD

Engineering thick tissues - The vascularisation problem

Ko, HCH Milthorpe, BK

McFarland, CD

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Publication Type:: Journal Article
Citation:: European Cells and Materials, 2007, 14 pp. 1 - 18
Issue Date:: 2007-01-01

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Field	Value	Language
dc.contributor.author	Ko, HCH	en_US
dc.contributor.author	Milthorpe, BK https://orcid.org/0000-0002-0867-9586	en_US
dc.contributor.author	McFarland, CD	en_US
dc.date.issued	2007-01-01	en_US
dc.identifier.citation	European Cells and Materials, 2007, 14 pp. 1 - 18	en_US
dc.identifier.issn	1473-2262	en_US
dc.identifier.uri	http://hdl.handle.net/10453/8832
dc.description.abstract	The ability to create thick tissues is a major tissue engineering challenge, requiring the development of a suitable vascular supply. Current trends are seeing the utilization of cells seeded into hybrid matrix/scaffold systems to create in vitro vascular analogues. Approaches that aim to create vasculature in vitro include the use of biological extracellular matrices such as collagen hydrogels, porous biodegradable polymeric scaffolds with macro- and micro-lumens and micro-channels, co-culture of cells, incorporation of growth factors, culture in dynamic bioreactor environments, and combinations of these. Of particular interest are those approaches that aim to create bioengineered tissues in vitro that can be readily connected to the host's vasculature following implantation in order to maintain cell viability.	en_US
dc.relation.ispartof	European Cells and Materials	en_US
dc.subject.classification	Biomedical Engineering	en_US
dc.subject.mesh	Blood Vessels	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Collagen	en_US
dc.subject.mesh	Biocompatible Materials	en_US
dc.subject.mesh	Tissue Engineering	en_US
dc.subject.mesh	Cell Adhesion	en_US
dc.subject.mesh	Neovascularization, Physiologic	en_US
dc.title	Engineering thick tissues - The vascularisation problem	en_US
dc.type	Journal Article
utslib.citation.volume	14	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	14	en_US

Abstract:

The ability to create thick tissues is a major tissue engineering challenge, requiring the development of a suitable vascular supply. Current trends are seeing the utilization of cells seeded into hybrid matrix/scaffold systems to create in vitro vascular analogues. Approaches that aim to create vasculature in vitro include the use of biological extracellular matrices such as collagen hydrogels, porous biodegradable polymeric scaffolds with macro- and micro-lumens and micro-channels, co-culture of cells, incorporation of growth factors, culture in dynamic bioreactor environments, and combinations of these. Of particular interest are those approaches that aim to create bioengineered tissues in vitro that can be readily connected to the host's vasculature following implantation in order to maintain cell viability.

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http://hdl.handle.net/10453/8832