Hydroxyapatite/PLA biocomposite thin films for slow drug delivery of antibiotics for the treatment of bone and implant-related infections

Macha, IJ; Ben-Nissan, B; Santos, J; Cazalbou, S; Milthorpe, B

Hydroxyapatite/PLA biocomposite thin films for slow drug delivery of antibiotics for the treatment of bone and implant-related infections

Macha, IJ Ben-Nissan, B Santos, J

Cazalbou, S Milthorpe, B

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Publication Type:: Journal Article
Citation:: Key Engineering Materials, 2016, 696 pp. 271 - 276
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Macha, IJ	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.contributor.author	Santos, J https://orcid.org/0000-0003-4067-220X	en_US
dc.contributor.author	Cazalbou, S	en_US
dc.contributor.author	Milthorpe, B https://orcid.org/0000-0002-0867-9586	en_US
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	Key Engineering Materials, 2016, 696 pp. 271 - 276	en_US
dc.identifier.isbn	9783035710403	en_US
dc.identifier.issn	1013-9826	en_US
dc.identifier.uri	http://hdl.handle.net/10453/88758
dc.description.abstract	© 2016 Trans Tech Publications, Switzerland. Drug delivery systems were developed from coralline hydroxyapatite (HAp) and biodegradable polylactic acid (PLA). Gentamicin (GM) was loaded in either directly to PLA (PLAGM) or in HAp microspheres. Drug loaded HAp was used to make thin film composites (PLAHApGM). Dissolution studies were carried out in phosphate buffered saline (PBS). The release profiles suggested that HAp particles improved drug stabilization and availability as well controlled the release rate. The release also displays a steady state release. In vitro studies in human Adipose Derived Stem Cells (hADSCs) showed substantial quantities of cells adhering to hydroxyapatite containing composites. The results suggested that the systems could be tailored to release different clinical active substances for a wide range of biomedical applications.	en_US
dc.relation.ispartof	Key Engineering Materials	en_US
dc.relation.isbasedon	10.4028/www.scientific.net/KEM.696.271	en_US
dc.subject.classification	Materials	en_US
dc.title	Hydroxyapatite/PLA biocomposite thin films for slow drug delivery of antibiotics for the treatment of bone and implant-related infections	en_US
dc.type	Journal Article
utslib.citation.volume	696	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	696	en_US

Abstract:

© 2016 Trans Tech Publications, Switzerland. Drug delivery systems were developed from coralline hydroxyapatite (HAp) and biodegradable polylactic acid (PLA). Gentamicin (GM) was loaded in either directly to PLA (PLAGM) or in HAp microspheres. Drug loaded HAp was used to make thin film composites (PLAHApGM). Dissolution studies were carried out in phosphate buffered saline (PBS). The release profiles suggested that HAp particles improved drug stabilization and availability as well controlled the release rate. The release also displays a steady state release. In vitro studies in human Adipose Derived Stem Cells (hADSCs) showed substantial quantities of cells adhering to hydroxyapatite containing composites. The results suggested that the systems could be tailored to release different clinical active substances for a wide range of biomedical applications.

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http://hdl.handle.net/10453/88758