Novel engineered ion channel provides controllable ion permeability for polyelectrolyte microcapsules coated with a lipid membrane

Battle, AR; Valenzuela, SM; Mechler, A; Nichols, RJ; Praporski, S; Di Maio, IL; Islam, H; Girard-Egrot, AP; Cornell, BA; Prashar, J; Caruso, F; Martin, LL; Martin, DK

Novel engineered ion channel provides controllable ion permeability for polyelectrolyte microcapsules coated with a lipid membrane

Battle, AR Valenzuela, SM

Mechler, A Nichols, RJ Praporski, S Di Maio, IL Islam, H Girard-Egrot, AP Cornell, BA

Prashar, J Caruso, F Martin, LL Martin, DK

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Publication Type:: Journal Article
Citation:: Advanced Functional Materials, 2009, 19 (2), pp. 201 - 208
Issue Date:: 2009-01-23

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Field	Value	Language
dc.contributor.author	Battle, AR	en_US
dc.contributor.author	Valenzuela, SM https://orcid.org/0000-0001-5934-6047	en_US
dc.contributor.author	Mechler, A	en_US
dc.contributor.author	Nichols, RJ	en_US
dc.contributor.author	Praporski, S	en_US
dc.contributor.author	Di Maio, IL	en_US
dc.contributor.author	Islam, H	en_US
dc.contributor.author	Girard-Egrot, AP	en_US
dc.contributor.author	Cornell, BA https://orcid.org/0000-0003-4166-3241	en_US
dc.contributor.author	Prashar, J	en_US
dc.contributor.author	Caruso, F	en_US
dc.contributor.author	Martin, LL	en_US
dc.contributor.author	Martin, DK https://orcid.org/0000-0001-5913-2372	en_US
dc.date.issued	2009-01-23	en_US
dc.identifier.citation	Advanced Functional Materials, 2009, 19 (2), pp. 201 - 208	en_US
dc.identifier.issn	1616-301X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/9168
dc.description.abstract	The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poIy(sodium styrenesutfbnate) (PSS)/poIy(alIylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bisgA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA.	en_US
dc.relation.ispartof	Advanced Functional Materials	en_US
dc.relation.isbasedon	10.1002/adfm.200800483	en_US
dc.subject.classification	Materials	en_US
dc.title	Novel engineered ion channel provides controllable ion permeability for polyelectrolyte microcapsules coated with a lipid membrane	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	19	en_US
utslib.for	091205 Functional Materials	en_US
utslib.for	02 Physical Sciences	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
dc.location.activity	ISI:000263082600002	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poIy(sodium styrenesutfbnate) (PSS)/poIy(alIylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bisgA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis-gA ion channels. This system provides a platform for the creation of "smart" biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/9168