Techniques and technologies for the bioanalysis of Sativex®, metabolites and related compounds

Molnar, A; Fu, S

Techniques and technologies for the bioanalysis of Sativex®, metabolites and related compounds

Molnar, A Fu, S

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Publication Type:: Journal Article
Citation:: Bioanalysis, 2016, 8 (8), pp. 829 - 845
Issue Date:: 2016-04-01

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Field	Value	Language
dc.contributor.author	Molnar, A	en_US
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612	en_US
dc.date.issued	2016-04-01	en_US
dc.identifier.citation	Bioanalysis, 2016, 8 (8), pp. 829 - 845	en_US
dc.identifier.issn	1757-6180	en_US
dc.identifier.uri	http://hdl.handle.net/10453/93145
dc.description.abstract	© 2016 Future Science Ltd. Sativex® is an oromucosal spray indicated for the treatment of moderate-to-severe spasticity in multiple sclerosis and is also an effective analgesic for advanced cancer patients. Sativex contains Δ9-tetrahydrocannabinol (THC) and cannabidiol in an approximately 1:1 ratio. The increasing prevalence of medicinal cannabis products highlights the importance of reliable bioanalysis and re-evaluation of the interpretation of positive test results for THC, as legal implications may arise in workplace, roadside and sports drug testing situations. This article summarizes published research on the bioanalysis of THC and cannabidiol, with particular focus on Sativex. Common screening and confirmatory testing of blood, urine, oral fluid and hair samples are outlined. Correlations between matrices and current analytical pitfalls are also addressed.	en_US
dc.relation.ispartof	Bioanalysis	en_US
dc.relation.isbasedon	10.4155/bio-2015-0021	en_US
dc.subject.mesh	Hair	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Multiple Sclerosis	en_US
dc.subject.mesh	Analgesics	en_US
dc.subject.mesh	Plant Extracts	en_US
dc.subject.mesh	Doping in Sports	en_US
dc.subject.mesh	Workplace	en_US
dc.subject.mesh	Gas Chromatography-Mass Spectrometry	en_US
dc.subject.mesh	Cannabidiol	en_US
dc.subject.mesh	Dronabinol	en_US
dc.subject.mesh	Drug Combinations	en_US
dc.title	Techniques and technologies for the bioanalysis of Sativex®, metabolites and related compounds	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	0301 Analytical Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

© 2016 Future Science Ltd. Sativex® is an oromucosal spray indicated for the treatment of moderate-to-severe spasticity in multiple sclerosis and is also an effective analgesic for advanced cancer patients. Sativex contains Δ9-tetrahydrocannabinol (THC) and cannabidiol in an approximately 1:1 ratio. The increasing prevalence of medicinal cannabis products highlights the importance of reliable bioanalysis and re-evaluation of the interpretation of positive test results for THC, as legal implications may arise in workplace, roadside and sports drug testing situations. This article summarizes published research on the bioanalysis of THC and cannabidiol, with particular focus on Sativex. Common screening and confirmatory testing of blood, urine, oral fluid and hair samples are outlined. Correlations between matrices and current analytical pitfalls are also addressed.

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http://hdl.handle.net/10453/93145