Bisphosphonate determination using H-1-NMR spectroscopy for biomedical applications

John Wiley & Sons Ltd
Publication Type:
Journal Article
Journal Of Tissue Engineering And Regenerative Medicine, 2009, 3 (2), pp. 92 - 96
Issue Date:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2008007871OK.pdf235.42 kB
Adobe PDF
Bisphosphonate is known to be a very active drug in the treatment of osteoporosis and bone regeneration. A new method has been developed, utilizing nuclear magnetic resonance spectroscopy to identify and measure the amount of bisphosphonate in solution. A standard reference with similar functional group to that of the bisphosphonate was chosen and applied in the experimentation. The results showed that the use of nuclear magnetic resonance spectroscopy (H-1-NMR) in determining the solvent residues of various pharmaceutical drugs has proved to be effective. Unlike chromatography, it is possible to use a universal reference standard as an internal standard assayed by quantitative NMR. Using the same theory, this method is capable of both identifying and quantifying the bisphosphonate in various solutions. This paper is the first publication showing this unique measurement method, which can be used in a range of pharmaceutical and biomedical applications.
Please use this identifier to cite or link to this item: