Electroencephalographic slowing and reduced reactivity in neuropathic pain following spinal cord injury

Boord, P; Siddall, PJ; Tran, Y; Herbert, D; Middleton, J; Craig, A

Electroencephalographic slowing and reduced reactivity in neuropathic pain following spinal cord injury

Boord, P Siddall, PJ Tran, Y

Herbert, D Middleton, J Craig, A

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Publication Type:: Journal Article
Citation:: Spinal Cord, 2008, 46 (2), pp. 118 - 123
Issue Date:: 2008-02-01

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Field	Value	Language
dc.contributor.author	Boord, P	en_US
dc.contributor.author	Siddall, PJ	en_US
dc.contributor.author	Tran, Y https://orcid.org/0000-0002-1741-4205	en_US
dc.contributor.author	Herbert, D	en_US
dc.contributor.author	Middleton, J	en_US
dc.contributor.author	Craig, A https://orcid.org/0000-0001-7647-7604	en_US
dc.date.issued	2008-02-01	en_US
dc.identifier.citation	Spinal Cord, 2008, 46 (2), pp. 118 - 123	en_US
dc.identifier.issn	1362-4393	en_US
dc.identifier.uri	http://hdl.handle.net/10453/9521
dc.description.abstract	Study Design: Brain wave activity in people with paraplegia, with and without neuropathic pain, was compared to brain wave activity in matched able-bodied controls. Objectives: To investigate whether spinal cord injury with neuropathic pain is associated with a slowing of brain wave activity. Setting: Australia. Methods: Electroencephalographic (EEG) data were collected in the eyes open (EO) and eyes closed (EC) states from 16 participants with paraplegia (eight with neuropathic pain and eight without pain) and matched able-bodied controls. Common EEG artefacts were removed using independent component analysis (ICA). Peak frequency in the θ-α band and EEG power in the δ, θ, α and β frequency bands were compared between groups. Results: The results show significant slowing of the EEG in people with neuropathic pain, consistent with the presence of thalamocortical dysrhythmia (TCD). Furthermore, people with neuropathic spinal cord injury (SCI) pain had significantly reduced EEG spectral reactivity in response to increased or decreased sensory input flowing into the thalamocortical network, as modulated by the eyes open and eyes closed states. Conclusion: The results provide further evidence for alterations in brain electric activity that may underlie the development of neuropathic pain following SCI. © 2008 International Spinal Cord Society All rights reserved.	en_US
dc.relation.ispartof	Spinal Cord	en_US
dc.relation.isbasedon	10.1038/sj.sc.3102077	en_US
dc.subject.classification	Rehabilitation	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Spinal Cord Injuries	en_US
dc.subject.mesh	Neuralgia	en_US
dc.subject.mesh	Paraplegia	en_US
dc.subject.mesh	Electroencephalography	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Electroencephalographic slowing and reduced reactivity in neuropathic pain following spinal cord injury	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	46	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	1106 Human Movement and Sports Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	46	en_US

Abstract:

Study Design: Brain wave activity in people with paraplegia, with and without neuropathic pain, was compared to brain wave activity in matched able-bodied controls. Objectives: To investigate whether spinal cord injury with neuropathic pain is associated with a slowing of brain wave activity. Setting: Australia. Methods: Electroencephalographic (EEG) data were collected in the eyes open (EO) and eyes closed (EC) states from 16 participants with paraplegia (eight with neuropathic pain and eight without pain) and matched able-bodied controls. Common EEG artefacts were removed using independent component analysis (ICA). Peak frequency in the θ-α band and EEG power in the δ, θ, α and β frequency bands were compared between groups. Results: The results show significant slowing of the EEG in people with neuropathic pain, consistent with the presence of thalamocortical dysrhythmia (TCD). Furthermore, people with neuropathic spinal cord injury (SCI) pain had significantly reduced EEG spectral reactivity in response to increased or decreased sensory input flowing into the thalamocortical network, as modulated by the eyes open and eyes closed states. Conclusion: The results provide further evidence for alterations in brain electric activity that may underlie the development of neuropathic pain following SCI. © 2008 International Spinal Cord Society All rights reserved.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/9521