Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment

Publisher:
Public library of Science
Publication Type:
Journal Article
Citation:
PLoS ONE, 2009, 4 (7), pp. 1 - 10
Issue Date:
2009-01
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Early life nutrition is critical for the development of hypothalamic neurons involved in energy homeostasis. We previously showed that intrauterine and early postnatal overnutrition programmed hypothalamic neurons expressing the appetite stimulator neuropeptide Y (NPY) and suppressor proopiomelanocortin (POMC) in offspring at weaning. However, the long-term effects of such programming and its interactions with post-weaning high-fat-diet (HFD) consumption are unclear.
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