Elemental bio-imaging of melanoma in lymph node biopsies

Publication Type:
Journal Article
Analyst, 2009, 134 (3), pp. 450 - 453
Issue Date:
Full metadata record
The spatial distribution of trace elements in human lymph nodes partially infiltrated by melanoma cells was determined by elemental bio-imaging. Imaging of 31P within the nodal capsule and normal lymph node tissue showed a clear demarcation of the tumour boundary, with a significant decrease in relative 31P concentration within the tumour. The location of the tumour boundary was confirmed by haematoxylin and eosin staining of serial sections and observation by light microscopy. Further enhancement of the tumour boundary was achieved by imaging the 31P/34S ratio. 31P/66Zn ratio images showed a decreasing ratio beyond the tumour boundary that extended into peritumour normal lymph node tissue. © The Royal Society of Chemistry.
Please use this identifier to cite or link to this item: