Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling

Publisher:
Elsevier Science Inc
Publication Type:
Journal Article
Citation:
Bone, 2008, 43 (4), pp. 653 - 662
Issue Date:
2008-01
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Introduction: It has been widely assumed that osteoclasts play a pivotal role during the entire process of fracture healing. Bisphosphonates (Bps) are anti-catabolic agents commonly used to treat metabolic bone diseases including osteoporosis, minimizing
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