Rational design of a comprehensive cancer therapy platform using temperature-sensitive polymer grafted hollow gold nanospheres: Simultaneous chemo/photothermal/photodynamic therapy triggered by a 650 nm laser with enhanced anti-tumor efficacy
- Publication Type:
- Journal Article
- Citation:
- Nanoscale, 2016, 8 (12), pp. 6837 - 6850
- Issue Date:
- 2016-03-28
Closed Access
Filename | Description | Size | |||
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RationalDesign.pdf | Published Version | 4.01 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Deng, X | en_US |
dc.contributor.author | Chen, Y | en_US |
dc.contributor.author | Cheng, Z | en_US |
dc.contributor.author | Deng, K | en_US |
dc.contributor.author | Ma, P | en_US |
dc.contributor.author | Hou, Z | en_US |
dc.contributor.author | Liu, B | en_US |
dc.contributor.author | Huang, S | en_US |
dc.contributor.author |
Jin, D https://orcid.org/0000-0003-1046-2666 |
en_US |
dc.contributor.author | Lin, J | en_US |
dc.date.issued | 2016-03-28 | en_US |
dc.identifier.citation | Nanoscale, 2016, 8 (12), pp. 6837 - 6850 | en_US |
dc.identifier.issn | 2040-3364 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/98649 | |
dc.description.abstract | © The Royal Society of Chemistry 2016. Combining multi-model treatments within one single system has attracted great interest for the purpose of synergistic therapy. In this paper, hollow gold nanospheres (HAuNs) coated with a temperature-sensitive polymer, poly(oligo(ethylene oxide) methacrylate-co-2-(2-methoxyethoxy)ethyl methacrylate) (p(OEGMA-co-MEMA)), co-loaded with DOX and a photosensitizer Chlorin e6 (Ce6) were successfully synthesized. As high as 58% DOX and 6% Ce6 by weight could be loaded onto the HAuNs-p(OEGMA-co-MEMA) nanocomposites. The grafting polymer brushes outside the HAuNs play the role of "gate molecules" for controlled drug release by 650 nm laser radiation owing to the temperature-sensitive property of the polymer and the photothermal effect of HAuNs. The HAuNs-p(OEGMA-co-MEMA)-Ce6-DOX nanocomposites with 650 nm laser radiation show effective inhibition of cancer cells in vitro and enhanced anti-tumor efficacy in vivo. In contrast, control groups without laser radiation show little cytotoxicity. The nanocomposite demonstrates a way of "killing three birds with one stone", that is, chemotherapy, photothermal and photodynamic therapy are triggered simultaneously by the 650 nm laser stimulation. Therefore, the nanocomposites show the great advantages of multi-modal synergistic effects for cancer therapy by a remote-controlled laser stimulus. | en_US |
dc.relation.ispartof | Nanoscale | en_US |
dc.relation.isbasedon | 10.1039/c5nr08253f | en_US |
dc.subject.classification | Nanoscience & Nanotechnology | en_US |
dc.subject.mesh | Cell Line, Tumor | en_US |
dc.subject.mesh | Hela Cells | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Neoplasms | en_US |
dc.subject.mesh | Disulfides | en_US |
dc.subject.mesh | Gold | en_US |
dc.subject.mesh | Reactive Oxygen Species | en_US |
dc.subject.mesh | Polymers | en_US |
dc.subject.mesh | Antineoplastic Agents | en_US |
dc.subject.mesh | Biocompatible Materials | en_US |
dc.subject.mesh | Photochemotherapy | en_US |
dc.subject.mesh | Drug Therapy | en_US |
dc.subject.mesh | Drug Delivery Systems | en_US |
dc.subject.mesh | Phototherapy | en_US |
dc.subject.mesh | X-Ray Diffraction | en_US |
dc.subject.mesh | Spectroscopy, Fourier Transform Infrared | en_US |
dc.subject.mesh | Lasers | en_US |
dc.subject.mesh | Temperature | en_US |
dc.subject.mesh | Nanocomposites | en_US |
dc.subject.mesh | Metal Nanoparticles | en_US |
dc.subject.mesh | Nanospheres | en_US |
dc.subject.mesh | Static Electricity | en_US |
dc.subject.mesh | HeLa Cells | en_US |
dc.title | Rational design of a comprehensive cancer therapy platform using temperature-sensitive polymer grafted hollow gold nanospheres: Simultaneous chemo/photothermal/photodynamic therapy triggered by a 650 nm laser with enhanced anti-tumor efficacy | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 12 | en_US |
utslib.citation.volume | 8 | en_US |
utslib.for | 1115 Pharmacology and Pharmaceutical Sciences | en_US |
utslib.for | 030607 Transport Properties and Non-Equilibrium Processes | en_US |
utslib.for | 02 Physical Sciences | en_US |
utslib.for | 03 Chemical Sciences | en_US |
utslib.for | 10 Technology | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | closed_access | |
pubs.issue | 12 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 8 | en_US |
Abstract:
© The Royal Society of Chemistry 2016. Combining multi-model treatments within one single system has attracted great interest for the purpose of synergistic therapy. In this paper, hollow gold nanospheres (HAuNs) coated with a temperature-sensitive polymer, poly(oligo(ethylene oxide) methacrylate-co-2-(2-methoxyethoxy)ethyl methacrylate) (p(OEGMA-co-MEMA)), co-loaded with DOX and a photosensitizer Chlorin e6 (Ce6) were successfully synthesized. As high as 58% DOX and 6% Ce6 by weight could be loaded onto the HAuNs-p(OEGMA-co-MEMA) nanocomposites. The grafting polymer brushes outside the HAuNs play the role of "gate molecules" for controlled drug release by 650 nm laser radiation owing to the temperature-sensitive property of the polymer and the photothermal effect of HAuNs. The HAuNs-p(OEGMA-co-MEMA)-Ce6-DOX nanocomposites with 650 nm laser radiation show effective inhibition of cancer cells in vitro and enhanced anti-tumor efficacy in vivo. In contrast, control groups without laser radiation show little cytotoxicity. The nanocomposite demonstrates a way of "killing three birds with one stone", that is, chemotherapy, photothermal and photodynamic therapy are triggered simultaneously by the 650 nm laser stimulation. Therefore, the nanocomposites show the great advantages of multi-modal synergistic effects for cancer therapy by a remote-controlled laser stimulus.
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