Browsing by Author Gardiner, DL

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Showing results 1 to 15 of 15
Issue DateTitleAuthor(s)
1-Jun-2012The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malariaSkinner-Adams, TS; Peatey, CL; Anderson, K; Trenholme, KR; Krige, D; Brown, CL; Stack, C; Nsangou, DMM; Mathews, RT; Thivierge, K; Dalton, JP; Gardiner, DL
25-Jun-2010Aminopeptidases of malaria parasites: New targets for chemotherapyTrenholme, KR; Brown, CL; Skinner-Adams, TS; Stack, C; Lowther, J; To, J; Robinson, MW; Donnelly, SM; Dalton, JP; Gardiner, DL
25-Jun-2012Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidasesThivierge, K; Mathew, RT; Nsangou, DMM; Da Silva, F; Cotton, S; Skinner-Adams, TS; Trenholme, KR; Brown, CL; Stack, CM; Gardiner, DL; Dalton, JP
19-Jan-2007Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: A protease involved in amino acid regulation with potential for antimalarial drug developmentStack, CM; Lowther, J; Cunningham, E; Donnelly, S; Gardiner, DL; Trenholme, KR; Skinner-Adams, TS; Teuscher, F; Grembecka, J; Mucha, A; Kafarski, P; Lua, L; Bell, A; Dalton, JP
2-May-2017The development of sexual stage malaria gametocytes in a Wave BioreactorDemanga, CG; Eng, JWL; Gardiner, DL; Roth, A; Butterworth, A; Adams, JH; Trenholme, KR; Dalton, JP
16-Feb-2012Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparumPoreba, M; McGowan, S; Skinner-Adams, TS; Trenholme, KR; Gardiner, DL; Whisstock, JC; To, J; Salvesen, GS; Dalton, JP; Drag, M
29-Nov-2007Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compoundsSkinner-Adams, TS; Lowther, J; Teuscher, F; Stack, CM; Grembecka, J; Mucha, A; Kafarski, P; Trenholme, KR; Dalton, JP; Gardiner, DL
1-Jan-2014Identification of potent and selective inhibitors of the plasmodium falciparum M18 aspartyl aminopeptidase (PfM18AAP) of human malaria via high-throughput screeningSpicer, T; Fernandez-Vega, V; Chase, P; Scampavia, L; To, J; Dalton, JP; Da Silva, FL; Skinner-Adams, TS; Gardiner, DL; Trenholme, KR; Brown, CL; Ghosh, P; Porubsky, P; Wang, JL; Whipple, DA; Schoenen, FJ; Hodder, P
16-Jun-2009The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: Importance of active site metal ions in the binding of substrates and inhibitorsMaric, S; Donnelly, SM; Robinson, MW; Skinner-Adams, T; Trenholme, KR; Gardiner, DL; Dalton, JP; Stack, CM; Lowther, J
19-Oct-2007The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparumTeuscher, F; Lowther, J; Skinner-Adams, TS; Spielmann, T; Dixon, MWA; Stack, CM; Donnelly, S; Mucha, A; Kafarski, P; Vassiliou, S; Gardiner, DL; Dalton, JP; Trenholme, KR
20-Jan-2006Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites: Target for the antimalarial activity of bestatinGardiner, DL; Trenholme, KR; Skinner-Adams, TS; Stack, CM; Dalton, JP
1-Oct-2016A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformabilityda Silva, FL; Dixon, MWA; Stack, CM; Teuscher, F; Taran, E; Jones, MK; Lovas, E; Tilley, L; Brown, CL; Trenholme, KR; Dalton, JP; Gardiner, DL; Skinner-Adams, TS
24-Feb-2009Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseMcGowan, S; Porter, CJ; Lowther, J; Stack, CM; Golding, SJ; Skinner-Adams, TS; Trenholme, KR; Teuscher, F; Donnelly, SM; Grembecka, J; Mucha, A; Kafarski, P; Degori, R; Buckle, AM; Gardiner, DL; Whisstock, JC; Dalton, JP
9-Feb-2010Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidasesMcGowan, S; Oellig, CA; Birru, WA; Caradoc-Davies, TT; Stack, CM; Lowther, J; Skinner-Adams, T; Mucha, A; Kafarski, P; Grembecka, J; Trenholme, KR; Buckle, AM; Gardiner, DL; Dalton, JP; Whisstock, JC
28-Sep-2012X-ray crystal structure and specificity of the plasmodium falciparum malaria aminopeptidase PfM18AAPSivaraman, KK; Oellig, CA; Huynh, K; Atkinson, SC; Poreba, M; Perugini, MA; Trenholme, KR; Gardiner, DL; Salvesen, G; Drag, M; Dalton, JP; Whisstock, JC; McGowan, S