Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria

El-Assaad, F; Combes, V; Raymond Grau, GE; Jamboua, R

Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria

El-Assaad, F Combes, V

Raymond Grau, GE Jamboua, R

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Publication Type:: Journal Article
Citation:: Antimicrobial Agents and Chemotherapy, 2014, 58 (1), pp. 602 - 605
Issue Date:: 2014-01-01

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Field	Value	Language
dc.contributor.author	El-Assaad, F	en_US
dc.contributor.author	Combes, V https://orcid.org/0000-0003-2178-3596	en_US
dc.contributor.author	Raymond Grau, GE	en_US
dc.contributor.author	Jamboua, R	en_US
dc.date.issued	2014-01-01	en_US
dc.identifier.citation	Antimicrobial Agents and Chemotherapy, 2014, 58 (1), pp. 602 - 605	en_US
dc.identifier.issn	0066-4804	en_US
dc.identifier.uri	http://hdl.handle.net/10453/115726
dc.description.abstract	Cerebral malaria (CM) is characterized by a dysregulated immune response that results in endothelial membrane destabilization and increased microparticle (MP) production. Citicoline (CTC) is a membrane stabilizer used for the treatment of neurological disorders. We evaluated the efficacy of CTC as adjunct therapy to aid recovery from experimental CM. We show that CTC reduces MP production in vitro; in combination with artesunate in vivo, confers partial protection against CM; and prolongs survival. © 2014, American Society for Microbiology. All Rights Reserved.	en_US
dc.relation.ispartof	Antimicrobial Agents and Chemotherapy	en_US
dc.relation.isbasedon	10.1128/AAC.02591-12	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Malaria, Cerebral	en_US
dc.subject.mesh	Cytidine Diphosphate Choline	en_US
dc.subject.mesh	Artemisinins	en_US
dc.subject.mesh	Antimalarials	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Artesunate	en_US
dc.title	Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	58	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	58	en_US

Abstract:

Cerebral malaria (CM) is characterized by a dysregulated immune response that results in endothelial membrane destabilization and increased microparticle (MP) production. Citicoline (CTC) is a membrane stabilizer used for the treatment of neurological disorders. We evaluated the efficacy of CTC as adjunct therapy to aid recovery from experimental CM. We show that CTC reduces MP production in vitro; in combination with artesunate in vivo, confers partial protection against CM; and prolongs survival. © 2014, American Society for Microbiology. All Rights Reserved.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/115726