Potential efficacy of citicoline as adjunct therapy in treatment of cerebral malaria.

American Society for Microbiology
Publication Type:
Journal Article
Antimicrobial Agents and Chemotherapy, 2014, 58 (1), pp. 602 - 605 (4)
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Cerebral malaria (CM) is characterized by a dysregulated immune response that results in endothelial membrane destabilization and increased microparticle (MP) production. Citicoline (CTC) is a membrane stabilizer used for the treatment of neurological disorders. We evaluated the efficacy of CTC as adjunct therapy to aid recovery from experimental CM. We show that CTC reduces MP production in vitro; in combination with artesunate in vivo, confers partial protection against CM; and prolongs survival.
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