Tackling dipeptidyl peptidase IV in neurological disorders

Al-Badri, G; Leggio, GM; Musumeci, G; Marzagalli, R; Drago, F; Castorina, A

Tackling dipeptidyl peptidase IV in neurological disorders

Al-Badri, G

Leggio, GM Musumeci, G Marzagalli, R Drago, F Castorina, A

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Publication Type:: Journal Article
Citation:: Neural Regeneration Research, 2018, 13 (1), pp. 26 - 34
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Al-Badri, G https://orcid.org/0000-0003-3342-2376	en_US
dc.contributor.author	Leggio, GM	en_US
dc.contributor.author	Musumeci, G	en_US
dc.contributor.author	Marzagalli, R	en_US
dc.contributor.author	Drago, F	en_US
dc.contributor.author	Castorina, A https://orcid.org/0000-0001-7037-759X	en_US
dc.date.available	2017-12-27	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	Neural Regeneration Research, 2018, 13 (1), pp. 26 - 34	en_US
dc.identifier.issn	1673-5374	en_US
dc.identifier.uri	http://hdl.handle.net/10453/122146
dc.description.abstract	© 2018, Medknow Publications. All rights reserved. Dipeptidyl peptidase IV (DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1 (GLP-1), pituitary adenylate cyclase-activating polypeptide (PACAP) and glucose-dependent insulinotropic peptide (GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells. In this review article, we aim at highlighting recent literature describing the therapeutic value of DPP-IV inhibitors for the treatment of such neurological conditions. Finally, we will illustrate some of the promising results obtained using berberine, a plant extract with potent inhibitory activity on DPP-IV.	en_US
dc.relation.ispartof	Neural Regeneration Research	en_US
dc.relation.isbasedon	10.4103/1673-5374.224365	en_US
dc.title	Tackling dipeptidyl peptidase IV in neurological disorders	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	13	en_US
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

© 2018, Medknow Publications. All rights reserved. Dipeptidyl peptidase IV (DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1 (GLP-1), pituitary adenylate cyclase-activating polypeptide (PACAP) and glucose-dependent insulinotropic peptide (GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells. In this review article, we aim at highlighting recent literature describing the therapeutic value of DPP-IV inhibitors for the treatment of such neurological conditions. Finally, we will illustrate some of the promising results obtained using berberine, a plant extract with potent inhibitory activity on DPP-IV.

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http://hdl.handle.net/10453/122146