Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling

McNally, R; Alqudah, A; Obradovic, D; McClements, L

Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling

McNally, R Alqudah, A Obradovic, D McClements, L

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Publication Type:: Journal Article
Citation:: Current Hypertension Reports, 2017, 19 (11)
Issue Date:: 2017-11-01

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Field	Value	Language
dc.contributor.author	McNally, R	en_US
dc.contributor.author	Alqudah, A	en_US
dc.contributor.author	Obradovic, D	en_US
dc.contributor.author	McClements, L https://orcid.org/0000-0002-4911-1014	en_US
dc.date.available	2020-05-25T19:02:38Z
dc.date.issued	2017-11-01	en_US
dc.identifier.citation	Current Hypertension Reports, 2017, 19 (11)	en_US
dc.identifier.issn	1522-6417	en_US
dc.identifier.uri	http://hdl.handle.net/10453/127142
dc.description.abstract	© 2017, The Author(s). Purpose of Review: The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed. Recent Findings: A number of proteins and microRNAs have been implicated as key in SUA remodelling, which could be explored as early biomarkers or therapeutic targets for prevention of pre-eclampsia. Summary: Various 2D and 3D in vitro models involving trophoblast cells, endothelial cells, immune cells and placental tissue were discussed to elucidate the pathogenesis of pre-eclampsia. Nevertheless, pre-eclampsia is a multifactorial disease, and the mechanisms involved in its pathogenesis are complex and still largely unknown. Further studies are required to provide better understanding of the key processes leading to inappropriate placental development which is the root cause of pre-eclampsia. This new knowledge could identify novel biomarkers and treatment strategies.	en_US
dc.relation.ispartof	Current Hypertension Reports	en_US
dc.relation.isbasedon	10.1007/s11906-017-0786-2	en_US
dc.subject.mesh	Endothelial Cells	en_US
dc.subject.mesh	Trophoblasts	en_US
dc.subject.mesh	Placenta	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Pre-Eclampsia	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Neovascularization, Physiologic	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Uterine Artery	en_US
dc.subject.mesh	In Vitro Techniques	en_US
dc.subject.mesh	Vascular Remodeling	en_US
dc.title	Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	19	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	1103 Clinical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

© 2017, The Author(s). Purpose of Review: The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed. Recent Findings: A number of proteins and microRNAs have been implicated as key in SUA remodelling, which could be explored as early biomarkers or therapeutic targets for prevention of pre-eclampsia. Summary: Various 2D and 3D in vitro models involving trophoblast cells, endothelial cells, immune cells and placental tissue were discussed to elucidate the pathogenesis of pre-eclampsia. Nevertheless, pre-eclampsia is a multifactorial disease, and the mechanisms involved in its pathogenesis are complex and still largely unknown. Further studies are required to provide better understanding of the key processes leading to inappropriate placental development which is the root cause of pre-eclampsia. This new knowledge could identify novel biomarkers and treatment strategies.

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http://hdl.handle.net/10453/127142