Functional relevance of SATB1 in immune regulation and tumorigenesis

Sunkara, KP; Gupta, G; Hansbro, PM; Dua, K; Bebawy, M

Functional relevance of SATB1 in immune regulation and tumorigenesis

Sunkara, KP Gupta, G Hansbro, PM

Dua, K

Bebawy, M

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Publication Type:: Journal Article
Citation:: Biomedicine and Pharmacotherapy, 2018, 104 pp. 87 - 93
Issue Date:: 2018-08-01

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Field	Value	Language
dc.contributor.author	Sunkara, KP	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Bebawy, M https://orcid.org/0000-0003-2606-921X	en_US
dc.date.available	2020-05-25T19:05:08Z
dc.date.issued	2018-08-01	en_US
dc.identifier.citation	Biomedicine and Pharmacotherapy, 2018, 104 pp. 87 - 93	en_US
dc.identifier.issn	0753-3322	en_US
dc.identifier.uri	http://hdl.handle.net/10453/128305
dc.description.abstract	© 2018 The Special AT-rich Sequence Binding Protein 1 (SATB1) is a chromatin organiser and transcription factor which regulates numerous cellular processes such as differentiation, proliferation and apoptosis through effects on gene expression. SATB1 undergoes various post-translational modifications, which determine its interaction with co-activators and co-repressors to induce regulation of gene transcription. SATB1 is an identified oncogene, its increased expression is associated with poor prognosis in many cancers. This paper provides a review on SATB1-mediated immune responses and on its target genes in the context of tumorigenesis and tumour progression. Specifically, we discuss the role of SATB1 in tumour immunity, Epithelial to Mesenchymal Transition (EMT), metastasis and multidrug resistance. Therapeutic targeting of aberrant SATB1 may be an important strategy in the treatment of cancer.	en_US
dc.relation.ispartof	Biomedicine and Pharmacotherapy	en_US
dc.relation.isbasedon	10.1016/j.biopha.2018.05.045	en_US
dc.subject.classification	Oncology & Carcinogenesis	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Neoplasms	en_US
dc.subject.mesh	Disease Progression	en_US
dc.subject.mesh	Matrix Attachment Region Binding Proteins	en_US
dc.subject.mesh	Immunity	en_US
dc.subject.mesh	Gene Expression Regulation, Neoplastic	en_US
dc.subject.mesh	Carcinogenesis	en_US
dc.title	Functional relevance of SATB1 in immune regulation and tumorigenesis	en_US
dc.type	Journal Article
utslib.citation.volume	104	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	104	en_US

Abstract:

© 2018 The Special AT-rich Sequence Binding Protein 1 (SATB1) is a chromatin organiser and transcription factor which regulates numerous cellular processes such as differentiation, proliferation and apoptosis through effects on gene expression. SATB1 undergoes various post-translational modifications, which determine its interaction with co-activators and co-repressors to induce regulation of gene transcription. SATB1 is an identified oncogene, its increased expression is associated with poor prognosis in many cancers. This paper provides a review on SATB1-mediated immune responses and on its target genes in the context of tumorigenesis and tumour progression. Specifically, we discuss the role of SATB1 in tumour immunity, Epithelial to Mesenchymal Transition (EMT), metastasis and multidrug resistance. Therapeutic targeting of aberrant SATB1 may be an important strategy in the treatment of cancer.

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http://hdl.handle.net/10453/128305