Quantitative imaging of translocated silver following nanoparticle exposure by laser ablation-inductively coupled plasma-mass spectrometry

Bishop, DP; Grossgarten, M; Dietrich, D; Vennemann, A; Cole, N; Sperling, M; Wiemann, M; Doble, PA; Karst, U

Quantitative imaging of translocated silver following nanoparticle exposure by laser ablation-inductively coupled plasma-mass spectrometry

Bishop, DP

Grossgarten, M Dietrich, D Vennemann, A Cole, N

Sperling, M Wiemann, M Doble, PA

Karst, U

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Publication Type:: Journal Article
Citation:: Analytical Methods, 2018, 10 (8), pp. 836 - 840
Issue Date:: 2018-02-28

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Field	Value	Language
dc.contributor.author	Bishop, DP https://orcid.org/0000-0002-6533-4410	en_US
dc.contributor.author	Grossgarten, M	en_US
dc.contributor.author	Dietrich, D	en_US
dc.contributor.author	Vennemann, A	en_US
dc.contributor.author	Cole, N https://orcid.org/0000-0002-9866-4694	en_US
dc.contributor.author	Sperling, M	en_US
dc.contributor.author	Wiemann, M	en_US
dc.contributor.author	Doble, PA https://orcid.org/0000-0002-8472-1301	en_US
dc.contributor.author	Karst, U	en_US
dc.date.issued	2018-02-28	en_US
dc.identifier.citation	Analytical Methods, 2018, 10 (8), pp. 836 - 840	en_US
dc.identifier.issn	1759-9660	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130949
dc.description.abstract	© 2018 The Royal Society of Chemistry. The likelihood of exposure to antimicrobial silver nanoparticles continues to grow with their increasing ubiquity in various medical and consumer products. While translocation of silver nanoparticles to major organs has been examined, the in situ location and concentration in the organs is not well characterised. Here we have used laser ablation-inductively coupled plasma-mass spectrometry to quantitatively image serial sections to construct a three-dimensional representation of the distribution of silver in rat spleen following respiratory tract exposure via intratracheal instillation of silver nanoparticles. Silver was distributed predominantly in the white pulp of the spleen at concentrations greater than 300 ng g-1. Imaging tissue sections via laser-ablation-inductively coupled plasma-mass spectrometry is an excellent tool for the visualisation and quantification of metals attributed to nanoparticles in organs allowing investigation of silver nanoparticle exposure in vivo.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DE180100194
dc.relation.ispartof	Analytical Methods	en_US
dc.relation.isbasedon	10.1039/c7ay02294h	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Quantitative imaging of translocated silver following nanoparticle exposure by laser ablation-inductively coupled plasma-mass spectrometry	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	10	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access	*
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

© 2018 The Royal Society of Chemistry. The likelihood of exposure to antimicrobial silver nanoparticles continues to grow with their increasing ubiquity in various medical and consumer products. While translocation of silver nanoparticles to major organs has been examined, the in situ location and concentration in the organs is not well characterised. Here we have used laser ablation-inductively coupled plasma-mass spectrometry to quantitatively image serial sections to construct a three-dimensional representation of the distribution of silver in rat spleen following respiratory tract exposure via intratracheal instillation of silver nanoparticles. Silver was distributed predominantly in the white pulp of the spleen at concentrations greater than 300 ng g-1. Imaging tissue sections via laser-ablation-inductively coupled plasma-mass spectrometry is an excellent tool for the visualisation and quantification of metals attributed to nanoparticles in organs allowing investigation of silver nanoparticle exposure in vivo.

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http://hdl.handle.net/10453/130949