Quantification method for elemental bio-imaging by LA-ICP-MS using metal spiked PMMA films

Austin, C; Hare, D; Rawling, T; McDonagh, AM; Doble, P

Quantification method for elemental bio-imaging by LA-ICP-MS using metal spiked PMMA films

Austin, C Hare, D

Rawling, T

McDonagh, AM

Doble, P

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Publication Type:: Journal Article
Citation:: Journal of Analytical Atomic Spectrometry, 2010, 25 (5), pp. 722 - 725
Issue Date:: 2010-05-10

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Field	Value	Language
dc.contributor.author	Austin, C	en_US
dc.contributor.author	Hare, D https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Rawling, T https://orcid.org/0000-0002-6624-6586	en_US
dc.contributor.author	McDonagh, AM https://orcid.org/0000-0002-9502-1175	en_US
dc.contributor.author	Doble, P https://orcid.org/0000-0002-8472-1301	en_US
dc.date.issued	2010-05-10	en_US
dc.identifier.citation	Journal of Analytical Atomic Spectrometry, 2010, 25 (5), pp. 722 - 725	en_US
dc.identifier.issn	0267-9477	en_US
dc.identifier.uri	http://hdl.handle.net/10453/13103
dc.description.abstract	A method for quantitative analysis of biological soft tissues by laser ablation-inductively coupled plasma-mass spectrometry has been developed. Polymer film standards were produced by spin coating spiked solutions of polymethylmethacrylate onto quartz substrates. Calibration curves throughout the range of 0-400 μg g-1 yielded correlation coefficients better than 0.999 for 66Zn and 63Cu. Spiked, homogenised soft tissue standards were quantified by LA-ICP-MS against the thin film standards. The results agreed with values calculated from solution nebulisation ICP-MS. A procedure for internal standardisation by employing ruthenium or yttrium in the underlying thin film was also assessed. © The Royal Society of Chemistry 2010.	en_US
dc.relation.ispartof	Journal of Analytical Atomic Spectrometry	en_US
dc.relation.isbasedon	10.1039/b911316a	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.title	Quantification method for elemental bio-imaging by LA-ICP-MS using metal spiked PMMA films	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	25	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0306 Physical Chemistry (incl. Structural)	en_US
utslib.for	0403 Geology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	25	en_US

Abstract:

A method for quantitative analysis of biological soft tissues by laser ablation-inductively coupled plasma-mass spectrometry has been developed. Polymer film standards were produced by spin coating spiked solutions of polymethylmethacrylate onto quartz substrates. Calibration curves throughout the range of 0-400 μg g-1 yielded correlation coefficients better than 0.999 for 66Zn and 63Cu. Spiked, homogenised soft tissue standards were quantified by LA-ICP-MS against the thin film standards. The results agreed with values calculated from solution nebulisation ICP-MS. A procedure for internal standardisation by employing ruthenium or yttrium in the underlying thin film was also assessed. © The Royal Society of Chemistry 2010.

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http://hdl.handle.net/10453/13103