Intercellular vesicular transfer by exosomes, microparticles and oncosomes - Implications for cancer biology and treatments

Jaiswal, R; Sedger, LM

Intercellular vesicular transfer by exosomes, microparticles and oncosomes - Implications for cancer biology and treatments

Jaiswal, R

Sedger, LM

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Publication Type:: Journal Article
Citation:: Frontiers in Oncology, 2019, 9 (MAR)
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Jaiswal, R https://orcid.org/0000-0002-8691-1352	en_US
dc.contributor.author	Sedger, LM https://orcid.org/0000-0003-1009-5683	en_US
dc.date.available	2019-02-12	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Frontiers in Oncology, 2019, 9 (MAR)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/133694
dc.description.abstract	Copyright © 2019 Jaiswal and Sedger. Intercellular communication is a normal feature of most physiological interactions between cells in healthy organisms. While cells communicate directly through intimate physiology contact, other mechanisms of communication exist, such as through the influence of soluble mediators such as growth factors, cytokines and chemokines. There is, however, yet another mechanism of intercellular communication that permits the exchange of information between cells through extracellular vesicles (EVs). EVs are microscopic (50 nm−10 μM) phospholipid bilayer enclosed entities produced by virtually all eukaryotic cells. EVs are abundant in the intracellular space and are present at a cells' normal microenvironment. Irrespective of the EV “donor” cell type, or the mechanism of EV biogenesis and production, or the size and EV composition, cancer cells have the potential to utilize EVs in a manner that enhances their survival. For example, cancer cell EV overproduction confers benefits to tumor growth, and tumor metastasis, compared with neighboring healthy cells. Herein, we summarize the current status of knowledge on different populations of EVs. We review the situations that regulate EV release, and the factors that instruct differential packaging or sorting of EV content. We then highlight the functions of cancer-cell derived EVs as they impact on cancer outcomes, promoting tumor progression, metastases, and the mechanisms by which they facilitate the creation of a pre-metastatic niche. The review finishes by focusing on the beneficial (and challenging) features of tumor-derived EVs that can be adapted and utilized for cancer treatments, including those already being investigated in human clinical trials.	en_US
dc.relation.ispartof	Frontiers in Oncology	en_US
dc.relation.isbasedon	10.3389/fonc.2019.00125	en_US
dc.title	Intercellular vesicular transfer by exosomes, microparticles and oncosomes - Implications for cancer biology and treatments	en_US
dc.type	Journal Article
utslib.citation.volume	MAR	en_US
utslib.citation.volume	9	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	MAR	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

Copyright © 2019 Jaiswal and Sedger. Intercellular communication is a normal feature of most physiological interactions between cells in healthy organisms. While cells communicate directly through intimate physiology contact, other mechanisms of communication exist, such as through the influence of soluble mediators such as growth factors, cytokines and chemokines. There is, however, yet another mechanism of intercellular communication that permits the exchange of information between cells through extracellular vesicles (EVs). EVs are microscopic (50 nm−10 μM) phospholipid bilayer enclosed entities produced by virtually all eukaryotic cells. EVs are abundant in the intracellular space and are present at a cells' normal microenvironment. Irrespective of the EV “donor” cell type, or the mechanism of EV biogenesis and production, or the size and EV composition, cancer cells have the potential to utilize EVs in a manner that enhances their survival. For example, cancer cell EV overproduction confers benefits to tumor growth, and tumor metastasis, compared with neighboring healthy cells. Herein, we summarize the current status of knowledge on different populations of EVs. We review the situations that regulate EV release, and the factors that instruct differential packaging or sorting of EV content. We then highlight the functions of cancer-cell derived EVs as they impact on cancer outcomes, promoting tumor progression, metastases, and the mechanisms by which they facilitate the creation of a pre-metastatic niche. The review finishes by focusing on the beneficial (and challenging) features of tumor-derived EVs that can be adapted and utilized for cancer treatments, including those already being investigated in human clinical trials.

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http://hdl.handle.net/10453/133694