Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats

Lee, HH; Paudel, KR; Jeong, J; Wi, AJ; Park, WS; Kim, DW; Oak, MH

Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats

Lee, HH Paudel, KR

Jeong, J Wi, AJ Park, WS Kim, DW Oak, MH

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Publication Type:: Journal Article
Citation:: Evidence-based Complementary and Alternative Medicine, 2016, 2016
Issue Date:: 2016-01-01

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Field	Value	Language
dc.contributor.author	Lee, HH	en_US
dc.contributor.author	Paudel, KR https://orcid.org/0000-0002-3591-2080	en_US
dc.contributor.author	Jeong, J	en_US
dc.contributor.author	Wi, AJ	en_US
dc.contributor.author	Park, WS	en_US
dc.contributor.author	Kim, DW	en_US
dc.contributor.author	Oak, MH	en_US
dc.date.available	2016-05-10	en_US
dc.date.issued	2016-01-01	en_US
dc.identifier.citation	Evidence-based Complementary and Alternative Medicine, 2016, 2016	en_US
dc.identifier.issn	1741-427X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/138440
dc.description.abstract	© 2016 Hyun-Ho Lee et al. Hypercholesterolemia is a well-known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. Camellia japonica is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study was carried out to evaluate the effect of C. japonica fruit extracts (CJF) in a high fat diet- (HFD-) induced hypercholesterolemic rat model. CJF was administered orally at three different doses: 100, 400, and 800 mg·kg-1·day-1 (CJF 100, 400, and 800, resp.). Our results showed that CJF possessed strong cholesterol-lowering potency as indicated by the decrease in serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), accompanied by an increase in serum high-density lipoprotein (HDL). Furthermore, CJF reduced serum lipid peroxidation by suppressing the formation of thiobarbituric acid reactive substance. In addition, oil red O (ORO) staining of rat arteries showed decreased lipid-positive staining in the CJF-treated groups compared to the control HFD group. Taken together, these results suggest that CJF could be a potent herbal therapeutic option and source of a functional food for the prevention and treatment of atherosclerosis and other diseases associated with hypercholesterolemia.	en_US
dc.relation.ispartof	Evidence-based Complementary and Alternative Medicine	en_US
dc.relation.isbasedon	10.1155/2016/9679867	en_US
dc.subject.classification	Complementary & Alternative Medicine	en_US
dc.title	Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats	en_US
dc.type	Journal Article
utslib.citation.volume	2016	en_US
utslib.for	1104 Complementary and Alternative Medicine	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	2016	en_US

Abstract:

© 2016 Hyun-Ho Lee et al. Hypercholesterolemia is a well-known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. Camellia japonica is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study was carried out to evaluate the effect of C. japonica fruit extracts (CJF) in a high fat diet- (HFD-) induced hypercholesterolemic rat model. CJF was administered orally at three different doses: 100, 400, and 800 mg·kg-1·day-1 (CJF 100, 400, and 800, resp.). Our results showed that CJF possessed strong cholesterol-lowering potency as indicated by the decrease in serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), accompanied by an increase in serum high-density lipoprotein (HDL). Furthermore, CJF reduced serum lipid peroxidation by suppressing the formation of thiobarbituric acid reactive substance. In addition, oil red O (ORO) staining of rat arteries showed decreased lipid-positive staining in the CJF-treated groups compared to the control HFD group. Taken together, these results suggest that CJF could be a potent herbal therapeutic option and source of a functional food for the prevention and treatment of atherosclerosis and other diseases associated with hypercholesterolemia.

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http://hdl.handle.net/10453/138440