Antiproliferative activities of tricyclic amides derived from β-caryophyllene via the Ritter reaction against MDA-MB-231 breast cancer cells

Royal Society of Chemistry (RSC)
Publication Type:
Journal Article
RSC Medicinal Chemistry, 2020, 11, (1), pp. 118-124
Issue Date:
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Tricyclic amides were successfully synthesised from β-caryophyllene via the Ritter reaction. Amides 3c and 6b inhibited proliferation of MDA-MB-231 cells. Compound 6b inhibited cell cycle progression and induced predominantly apoptotic cell death.

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