Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond

Chen, H; Oliver, BG; Pant, A; Olivera, A; Poronnik, P; Pollock, CA; Saad, S

Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond

Chen, H

Oliver, BG Pant, A Olivera, A Poronnik, P Pollock, CA Saad, S

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Antioxidants, 10, (5), pp. 732-732

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Field	Value	Language
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752
dc.contributor.author	Oliver, BG
dc.contributor.author	Pant, A
dc.contributor.author	Olivera, A
dc.contributor.author	Poronnik, P
dc.contributor.author	Pollock, CA
dc.contributor.author	Saad, S
dc.date.accessioned	2021-05-11T03:27:04Z
dc.date.available	2021-05-11T03:27:04Z
dc.identifier.citation	Antioxidants, 10, (5), pp. 732-732
dc.identifier.issn	2076-3921
dc.identifier.uri	http://hdl.handle.net/10453/148840
dc.description.abstract	<jats:p>Air pollution is the 9th cause of the overall disease burden globally. The solid component in the polluted air, particulate matters (PMs) with a diameter of 2.5 μm or smaller (PM2.5) possess a significant health risk to several organ systems. PM2.5 has also been shown to cross the blood–placental barrier and circulate in foetal blood. Therefore, it is considered an intrauterine environmental toxin. Exposure to PM2.5 during the perinatal period, when the foetus is particularly susceptible to developmental defects, has been shown to reduce birth weight and cause preterm birth, with an increase in adult disease susceptibility in the offspring. However, few studies have thoroughly studied the health outcome of foetuses due to intrauterine exposure and the underlying mechanisms. This perspective summarises currently available evidence, which suggests that intrauterine exposure to PM2.5 promotes oxidative stress and inflammation in a similar manner as occurs in response to direct PM exposure. Oxidative stress and inflammation are likely to be the common mechanisms underlying the dysfunction of multiple systems, offering potential targets for preventative strategies in pregnant mothers for an optimal foetal outcome.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1158186
dc.relation.ispartof	Antioxidants
dc.relation.isbasedon	10.3390/antiox10050732
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond
dc.type	Journal Article
utslib.citation.volume	10
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
dc.date.updated	2021-05-11T03:27:03Z
pubs.issue	5
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	5

Abstract:

Air pollution is the 9th cause of the overall disease burden globally. The solid component in the polluted air, particulate matters (PMs) with a diameter of 2.5 μm or smaller (PM2.5) possess a significant health risk to several organ systems. PM2.5 has also been shown to cross the blood–placental barrier and circulate in foetal blood. Therefore, it is considered an intrauterine environmental toxin. Exposure to PM2.5 during the perinatal period, when the foetus is particularly susceptible to developmental defects, has been shown to reduce birth weight and cause preterm birth, with an increase in adult disease susceptibility in the offspring. However, few studies have thoroughly studied the health outcome of foetuses due to intrauterine exposure and the underlying mechanisms. This perspective summarises currently available evidence, which suggests that intrauterine exposure to PM2.5 promotes oxidative stress and inflammation in a similar manner as occurs in response to direct PM exposure. Oxidative stress and inflammation are likely to be the common mechanisms underlying the dysfunction of multiple systems, offering potential targets for preventative strategies in pregnant mothers for an optimal foetal outcome.

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http://hdl.handle.net/10453/148840