Targets and regulation of microRNA-652-3p in homoeostasis and disease.

Stevens, MT; Saunders, BM

Targets and regulation of microRNA-652-3p in homoeostasis and disease.

Stevens, MT Saunders, BM

Permalink

Publisher:: SPRINGER HEIDELBERG
Publication Type:: Journal Article
Citation:: J Mol Med (Berl), 2021, 99, (6), pp. 755-769
Issue Date:: 2021-06

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

The embargo period expires on 30 Jun 2022

Adobe PDF

Download Accepted versionAdobe PDF (561.61 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Stevens, MT
dc.contributor.author	Saunders, BM
dc.date.accessioned	2022-01-11T07:20:12Z
dc.date.available	2021-03-01
dc.date.available	2022-01-11T07:20:12Z
dc.date.issued	2021-06
dc.identifier.citation	J Mol Med (Berl), 2021, 99, (6), pp. 755-769
dc.identifier.issn	0946-2716
dc.identifier.issn	1432-1440
dc.identifier.uri	http://hdl.handle.net/10453/152923
dc.description.abstract	microRNA are small non-coding RNA molecules which inhibit gene expression by binding mRNA, preventing its translation. As important regulators of gene expression, there is increasing interest in microRNAs as potential diagnostic biomarkers and therapeutic targets. Studies investigating the role of one of the miRNA-miR-652-3p-detail diverse roles for this miRNA in normal cell homoeostasis and disease states, including cancers, cardiovascular disease, mental health, and central nervous system diseases. Here, we review recent literature surrounding miR-652-3p, discussing its known target genes and their relevance to disease progression. These studies demonstrate that miR-652-3p targets LLGL1 and ZEB1 to modulate cell polarity mechanisms, with impacts on cancer metastasis and asymmetric cell division. Inhibition of the NOTCH ligand JAG1 by miR-652-3p can have diverse effects on angiogenesis and immune cell regulation. Investigation of miR-652-3p and other dysregulated miRNAs identified a number of pathways potentially regulated by miR-652-3p. This review demonstrates that miR-652-3p has great promise as a diagnostic or therapeutic target due to its activity across multiple cellular systems.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER HEIDELBERG
dc.relation.ispartof	J Mol Med (Berl)
dc.relation.isbasedon	10.1007/s00109-021-02060-8
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.rights	The final publication is available at Springer via http://dx.doi.org/ 10.1007/s00109-021-02060-8
dc.subject	0304 Medicinal and Biomolecular Chemistry
dc.subject.classification	Immunology
dc.title	Targets and regulation of microRNA-652-3p in homoeostasis and disease.
dc.type	Journal Article
utslib.citation.volume	99
utslib.location.activity	Germany
utslib.for	0304 Medicinal and Biomolecular Chemistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2022-06-30T00:00:00+1000Z
dc.date.updated	2022-01-11T07:20:05Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	99
utslib.citation.issue	6

Abstract:

microRNA are small non-coding RNA molecules which inhibit gene expression by binding mRNA, preventing its translation. As important regulators of gene expression, there is increasing interest in microRNAs as potential diagnostic biomarkers and therapeutic targets. Studies investigating the role of one of the miRNA-miR-652-3p-detail diverse roles for this miRNA in normal cell homoeostasis and disease states, including cancers, cardiovascular disease, mental health, and central nervous system diseases. Here, we review recent literature surrounding miR-652-3p, discussing its known target genes and their relevance to disease progression. These studies demonstrate that miR-652-3p targets LLGL1 and ZEB1 to modulate cell polarity mechanisms, with impacts on cancer metastasis and asymmetric cell division. Inhibition of the NOTCH ligand JAG1 by miR-652-3p can have diverse effects on angiogenesis and immune cell regulation. Investigation of miR-652-3p and other dysregulated miRNAs identified a number of pathways potentially regulated by miR-652-3p. This review demonstrates that miR-652-3p has great promise as a diagnostic or therapeutic target due to its activity across multiple cellular systems.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/152923