Efficacy of exercise rehabilitation for managing patients with Alzheimer’s disease

Li, D; Jia, J; Zeng, H; Zhong, X; Chen, H; Yi, C

Efficacy of exercise rehabilitation for managing patients with Alzheimer’s disease

Li, D Jia, J Zeng, H Zhong, X Chen, H

Yi, C

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Publisher:: Wolters Kluwer
Publication Type:: Journal Article
Citation:: Neural Regeneration Research

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Field	Value	Language
dc.contributor.author	Li, D
dc.contributor.author	Jia, J
dc.contributor.author	Zeng, H
dc.contributor.author	Zhong, X
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752
dc.contributor.author	Yi, C
dc.date.accessioned	2024-01-15T05:55:21Z
dc.date.available	2024-01-15T05:55:21Z
dc.identifier.citation	Neural Regeneration Research
dc.identifier.issn	1673-5374
dc.identifier.issn	1876-7958
dc.identifier.uri	http://hdl.handle.net/10453/174483
dc.description.abstract	<jats:title>Abstract</jats:title> <jats:p>Alzheimer’s disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.</jats:p>
dc.language	en
dc.publisher	Wolters Kluwer
dc.relation.ispartof	Neural Regeneration Research
dc.relation.isbasedon	10.4103/1673-5374.391308
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	1109 Neurosciences
dc.subject.classification	3209 Neurosciences
dc.title	Efficacy of exercise rehabilitation for managing patients with Alzheimer’s disease
dc.type	Journal Article
utslib.for	1109 Neurosciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	in_progress	*
dc.date.updated	2024-01-15T05:55:20Z
pubs.publication-status	Published online

Abstract:

Abstract Alzheimer’s disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

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http://hdl.handle.net/10453/174483