Sexual dimorphism in chronic respiratory diseases.

Reddy, KD; Oliver, BGG

Sexual dimorphism in chronic respiratory diseases.

Reddy, KD Oliver, BGG

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Publisher:: BMC
Publication Type:: Journal Article
Citation:: Cell Biosci, 2023, 13, (1), pp. 47
Issue Date:: 2023-03-07

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Field	Value	Language
dc.contributor.author	Reddy, KD
dc.contributor.author	Oliver, BGG
dc.date.accessioned	2024-02-12T06:40:16Z
dc.date.available	2023-02-23
dc.date.available	2024-02-12T06:40:16Z
dc.date.issued	2023-03-07
dc.identifier.citation	Cell Biosci, 2023, 13, (1), pp. 47
dc.identifier.issn	2045-3701
dc.identifier.issn	2045-3701
dc.identifier.uri	http://hdl.handle.net/10453/175593
dc.description.abstract	Sex differences in susceptibility, severity, and progression are prevalent for various diseases in multiple organ systems. This phenomenon is particularly apparent in respiratory diseases. Asthma demonstrates an age-dependent pattern of sexual dimorphism. However, marked differences between males and females exist in other pervasive conditions such as chronic obstructive pulmonary disease (COPD) and lung cancer. The sex hormones estrogen and testosterone are commonly considered the primary factors causing sexual dimorphism in disease. However, how they contribute to differences in disease onset between males and females remains undefined. The sex chromosomes are an under-investigated fundamental form of sexual dimorphism. Recent studies highlight key X and Y-chromosome-linked genes that regulate vital cell processes and can contribute to disease-relevant mechanisms. This review summarises patterns of sex differences in asthma, COPD and lung cancer, highlighting physiological mechanisms causing the observed dimorphism. We also describe the role of the sex hormones and present candidate genes on the sex chromosomes as potential factors contributing to sexual dimorphism in disease.
dc.format	Electronic
dc.language	eng
dc.publisher	BMC
dc.relation.ispartof	Cell Biosci
dc.relation.isbasedon	10.1186/s13578-023-00998-5
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Sexual dimorphism in chronic respiratory diseases.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	England
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2024-02-12T06:40:15Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	13
utslib.citation.issue	1

Abstract:

Sex differences in susceptibility, severity, and progression are prevalent for various diseases in multiple organ systems. This phenomenon is particularly apparent in respiratory diseases. Asthma demonstrates an age-dependent pattern of sexual dimorphism. However, marked differences between males and females exist in other pervasive conditions such as chronic obstructive pulmonary disease (COPD) and lung cancer. The sex hormones estrogen and testosterone are commonly considered the primary factors causing sexual dimorphism in disease. However, how they contribute to differences in disease onset between males and females remains undefined. The sex chromosomes are an under-investigated fundamental form of sexual dimorphism. Recent studies highlight key X and Y-chromosome-linked genes that regulate vital cell processes and can contribute to disease-relevant mechanisms. This review summarises patterns of sex differences in asthma, COPD and lung cancer, highlighting physiological mechanisms causing the observed dimorphism. We also describe the role of the sex hormones and present candidate genes on the sex chromosomes as potential factors contributing to sexual dimorphism in disease.

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http://hdl.handle.net/10453/175593