Anti-proliferative actions of N '-desmethylsorafenib in human breast cancer cells

Pergamon-Elsevier Science Ltd
Publication Type:
Journal Article
Biochemical Pharmacology, 2013, 86 (3), pp. 419 - 427
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d The multi-kinase inhibitor sorafenib is used for the treatment of renal and hepatic carcinomas and is undergoing evaluation for treatment of breast cancer in combination with other agents. Cytochrome P450 (CYP) 3A4 converts sorafenib to multiple metabo
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