The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis

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Journal Article
Tetrahedron, 2009, 65 (31), pp. 5990 - 6000
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Novel laudanosine dimers in which two laudanosine units are linked at C-2′ via a two and four-carbon linker have been prepared using ruthenium-mediated olefin-metathesis. In addition, a second four-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Five of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright © 2009.
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