The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis

Mbere-Nguyen, U; Ung, AT; Pyne, SG

The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis

Mbere-Nguyen, U Ung, AT

Pyne, SG

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Publication Type:: Journal Article
Citation:: Tetrahedron, 2009, 65 (31), pp. 5990 - 6000
Issue Date:: 2009-08-01

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Field	Value	Language
dc.contributor.author	Mbere-Nguyen, U	en_US
dc.contributor.author	Ung, AT https://orcid.org/0000-0002-5665-0702	en_US
dc.contributor.author	Pyne, SG	en_US
dc.date.issued	2009-08-01	en_US
dc.identifier.citation	Tetrahedron, 2009, 65 (31), pp. 5990 - 6000	en_US
dc.identifier.issn	0040-4020	en_US
dc.identifier.uri	http://hdl.handle.net/10453/32503
dc.description.abstract	Novel laudanosine dimers in which two laudanosine units are linked at C-2′ via a two and four-carbon linker have been prepared using ruthenium-mediated olefin-metathesis. In addition, a second four-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Five of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright © 2009.	en_US
dc.relation.ispartof	Tetrahedron	en_US
dc.relation.isbasedon	10.1016/j.tet.2009.05.094	en_US
dc.subject.classification	Organic Chemistry	en_US
dc.title	The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis	en_US
dc.type	Journal Article
utslib.citation.volume	31	en_US
utslib.citation.volume	65	en_US
utslib.for	0305 Organic Chemistry	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	closed_access
pubs.issue	31	en_US
pubs.publication-status	Published	en_US
pubs.volume	65	en_US

Abstract:

Novel laudanosine dimers in which two laudanosine units are linked at C-2′ via a two and four-carbon linker have been prepared using ruthenium-mediated olefin-metathesis. In addition, a second four-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system. Five of these compounds showed higher cytostatic activity on three cancer cell lines than thalicarpine. Crown Copyright © 2009.

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http://hdl.handle.net/10453/32503