A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases.

Publication Type:
Journal Article
Citation:
Nature communications, 2015, 6 pp. 6563 - ?
Issue Date:
2015-01
Full metadata record
Files in This Item:
Filename Description Size
Thumbnailncomms7563.pdfPublished Version311.68 kB
Adobe PDF
Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene.
Please use this identifier to cite or link to this item: