A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases

Dontschuk, N; Stacey, A; Tadich, A; Rietwyk, KJ; Schenk, A; Edmonds, MT; Shimoni, O; Pakes, CI; Prawer, S; Cervenka, J

A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases

Dontschuk, N Stacey, A Tadich, A Rietwyk, KJ Schenk, A Edmonds, MT Shimoni, O

Pakes, CI Prawer, S Cervenka, J

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Publication Type:: Journal Article
Citation:: Nature Communications, 2015, 6
Issue Date:: 2015-03-24

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Field	Value	Language
dc.contributor.author	Dontschuk, N	en_US
dc.contributor.author	Stacey, A	en_US
dc.contributor.author	Tadich, A	en_US
dc.contributor.author	Rietwyk, KJ	en_US
dc.contributor.author	Schenk, A	en_US
dc.contributor.author	Edmonds, MT	en_US
dc.contributor.author	Shimoni, O https://orcid.org/0000-0001-8822-1024	en_US
dc.contributor.author	Pakes, CI	en_US
dc.contributor.author	Prawer, S	en_US
dc.contributor.author	Cervenka, J	en_US
dc.date.available	2015-02-09	en_US
dc.date.issued	2015-03-24	en_US
dc.identifier.citation	Nature Communications, 2015, 6	en_US
dc.identifier.uri	http://hdl.handle.net/10453/35344
dc.description.abstract	© 2015 Macmillan Publishers Limited. All rights reserved. Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene.	en_US
dc.relation.ispartof	Nature Communications	en_US
dc.relation.isbasedon	10.1038/ncomms7563	en_US
dc.subject.mesh	Graphite	en_US
dc.subject.mesh	Cytosine	en_US
dc.subject.mesh	Thymine	en_US
dc.subject.mesh	Adenine	en_US
dc.subject.mesh	Guanine	en_US
dc.subject.mesh	DNA	en_US
dc.subject.mesh	DNA Probes	en_US
dc.subject.mesh	Sequence Analysis, DNA	en_US
dc.subject.mesh	Base Sequence	en_US
dc.subject.mesh	Adsorption	en_US
dc.subject.mesh	Transistors, Electronic	en_US
dc.title	A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.for	090303 Biomedical Instrumentation	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	6	en_US

Abstract:

© 2015 Macmillan Publishers Limited. All rights reserved. Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene.

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http://hdl.handle.net/10453/35344