Absence of back to school peaks in human rhinovirus detections and respiratory symptoms in a cohort of children with asthma

Stelzer-Braid, S; Tovey, ER; Willenborg, CM; Toelle, BG; Ampon, R; Garden, FL; Oliver, BG; Strachan, R; Belessis, Y; Jaffe, A; Reddel, HK; Crisafulli, D; Marks, GB; Rawlinson, WD

Absence of back to school peaks in human rhinovirus detections and respiratory symptoms in a cohort of children with asthma

Stelzer-Braid, S

Tovey, ER Willenborg, CM Toelle, BG Ampon, R Garden, FL Oliver, BG

Strachan, R Belessis, Y Jaffe, A Reddel, HK Crisafulli, D Marks, GB Rawlinson, WD

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Publication Type:: Journal Article
Citation:: Journal of Medical Virology, 2016, 88 (4), pp. 578 - 587
Issue Date:: 2016-04-01

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Field	Value	Language
dc.contributor.author	Stelzer-Braid, S https://orcid.org/0000-0001-6037-9305	en_US
dc.contributor.author	Tovey, ER	en_US
dc.contributor.author	Willenborg, CM	en_US
dc.contributor.author	Toelle, BG	en_US
dc.contributor.author	Ampon, R	en_US
dc.contributor.author	Garden, FL	en_US
dc.contributor.author	Oliver, BG https://orcid.org/0000-0002-7122-9262	en_US
dc.contributor.author	Strachan, R	en_US
dc.contributor.author	Belessis, Y	en_US
dc.contributor.author	Jaffe, A	en_US
dc.contributor.author	Reddel, HK	en_US
dc.contributor.author	Crisafulli, D	en_US
dc.contributor.author	Marks, GB	en_US
dc.contributor.author	Rawlinson, WD	en_US
dc.date.available	2015-08-20	en_US
dc.date.issued	2016-04-01	en_US
dc.identifier.citation	Journal of Medical Virology, 2016, 88 (4), pp. 578 - 587	en_US
dc.identifier.issn	0146-6615	en_US
dc.identifier.uri	http://hdl.handle.net/10453/41763
dc.description.abstract	© 2016 Wiley Periodicals, Inc. Much of what is known about the seasonality of human rhinovirus (hRV) infections has been learned from the study of acute asthma exacerbations presenting to emergency care, including those among children at the start of the school term. Much less is known about the patterns of hRVs in the community. In this study, viruses and day-to-day symptoms of asthma and colds were monitored twice weekly in 67 children with asthma aged 5-12 years, over a 15 month period in Sydney, Australia. Overall hRV was detected in 314/1232 (25.5%) of nasal wash samples and 142/1231 (11.5%) of exhaled breath samples; of these, 231 and 24 respectively were genotyped. HRVs were detected with similar prevalence rate throughout the year, including no peak in hRV prevalence following return to school. No peaks were seen in asthma and cold symptoms using twice-weekly diary records. However, over the same period in the community, there were peaks in asthma emergency visits both at a large local hospital and in state-wide hospitalizations, following both return to school (February) and in late autumn (May) in children of the same age. This study suggests that hRV infections are common throughout the year among children, and differences in virus prevalence alone may not account for peaks in asthma symptoms.	en_US
dc.relation.ispartof	Journal of Medical Virology	en_US
dc.relation.isbasedon	10.1002/jmv.24371	en_US
dc.subject.classification	Virology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Rhinovirus	en_US
dc.subject.mesh	Common Cold	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Incidence	en_US
dc.subject.mesh	Prevalence	en_US
dc.subject.mesh	Longitudinal Studies	en_US
dc.subject.mesh	Seasons	en_US
dc.subject.mesh	Schools	en_US
dc.subject.mesh	Students	en_US
dc.subject.mesh	Child	en_US
dc.subject.mesh	Child, Preschool	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.title	Absence of back to school peaks in human rhinovirus detections and respiratory symptoms in a cohort of children with asthma	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	88	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	88	en_US

Abstract:

© 2016 Wiley Periodicals, Inc. Much of what is known about the seasonality of human rhinovirus (hRV) infections has been learned from the study of acute asthma exacerbations presenting to emergency care, including those among children at the start of the school term. Much less is known about the patterns of hRVs in the community. In this study, viruses and day-to-day symptoms of asthma and colds were monitored twice weekly in 67 children with asthma aged 5-12 years, over a 15 month period in Sydney, Australia. Overall hRV was detected in 314/1232 (25.5%) of nasal wash samples and 142/1231 (11.5%) of exhaled breath samples; of these, 231 and 24 respectively were genotyped. HRVs were detected with similar prevalence rate throughout the year, including no peak in hRV prevalence following return to school. No peaks were seen in asthma and cold symptoms using twice-weekly diary records. However, over the same period in the community, there were peaks in asthma emergency visits both at a large local hospital and in state-wide hospitalizations, following both return to school (February) and in late autumn (May) in children of the same age. This study suggests that hRV infections are common throughout the year among children, and differences in virus prevalence alone may not account for peaks in asthma symptoms.

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http://hdl.handle.net/10453/41763