Capillary-driven microfluidic paper-based analytical devices for lab on a chip screening of explosive residues in soil

Ueland, M; Blanes, L; Taudte, RV; Stuart, BH; Cole, N; Willis, P; Roux, C; Doble, P

Capillary-driven microfluidic paper-based analytical devices for lab on a chip screening of explosive residues in soil

Ueland, M

Blanes, L Taudte, RV

Stuart, BH

Cole, N

Willis, P Roux, C

Doble, P

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Publication Type:: Journal Article
Citation:: Journal of Chromatography A, 2016, 1436 pp. 28 - 33
Issue Date:: 2016-03-04

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Field	Value	Language
dc.contributor.author	Ueland, M https://orcid.org/0000-0002-9155-3502	en_US
dc.contributor.author	Blanes, L	en_US
dc.contributor.author	Taudte, RV https://orcid.org/0000-0003-4617-6063	en_US
dc.contributor.author	Stuart, BH https://orcid.org/0000-0001-9540-4435	en_US
dc.contributor.author	Cole, N https://orcid.org/0000-0002-9866-4694	en_US
dc.contributor.author	Willis, P	en_US
dc.contributor.author	Roux, C https://orcid.org/0000-0003-3610-420X	en_US
dc.contributor.author	Doble, P https://orcid.org/0000-0002-8472-1301	en_US
dc.date.available	2020-05-25T19:18:29Z
dc.date.issued	2016-03-04	en_US
dc.identifier.citation	Journal of Chromatography A, 2016, 1436 pp. 28 - 33	en_US
dc.identifier.issn	0021-9673	en_US
dc.identifier.uri	http://hdl.handle.net/10453/45490
dc.description.abstract	© 2016 Elsevier B.V.. A novel microfluidic paper-based analytical device (μPAD) was designed to filter, extract, and pre-concentrate explosives from soil for direct analysis by a lab on a chip (LOC) device. The explosives were extracted via immersion of wax-printed μPADs directly into methanol soil suspensions for 10 min, whereby dissolved explosives travelled upwards into the μPAD circular sampling reservoir. A chad was punched from the sampling reservoir and inserted into a LOC well containing the separation buffer for direct analysis, avoiding any further extraction step. Eight target explosives were separated and identified by fluorescence quenching. The minimum detectable amounts for all eight explosives were between 1.4 and 5.6 ng with recoveries ranging from 53-82% from the paper chad, and 12-40% from soil. This method provides a robust and simple extraction method for rapid identification of explosives in complex soil samples.	en_US
dc.relation	http://purl.org/au-research/grants/arc/LP120200079
dc.relation.ispartof	Journal of Chromatography A	en_US
dc.relation.isbasedon	10.1016/j.chroma.2016.01.054	en_US
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Soil	en_US
dc.subject.mesh	Microfluidic Analytical Techniques	en_US
dc.subject.mesh	Paper	en_US
dc.subject.mesh	Explosive Agents	en_US
dc.subject.mesh	Lab-On-A-Chip Devices	en_US
dc.title	Capillary-driven microfluidic paper-based analytical devices for lab on a chip screening of explosive residues in soil	en_US
dc.type	Journal Article
utslib.citation.volume	1436	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	10 Technology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	1436	en_US

Abstract:

© 2016 Elsevier B.V.. A novel microfluidic paper-based analytical device (μPAD) was designed to filter, extract, and pre-concentrate explosives from soil for direct analysis by a lab on a chip (LOC) device. The explosives were extracted via immersion of wax-printed μPADs directly into methanol soil suspensions for 10 min, whereby dissolved explosives travelled upwards into the μPAD circular sampling reservoir. A chad was punched from the sampling reservoir and inserted into a LOC well containing the separation buffer for direct analysis, avoiding any further extraction step. Eight target explosives were separated and identified by fluorescence quenching. The minimum detectable amounts for all eight explosives were between 1.4 and 5.6 ng with recoveries ranging from 53-82% from the paper chad, and 12-40% from soil. This method provides a robust and simple extraction method for rapid identification of explosives in complex soil samples.

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http://hdl.handle.net/10453/45490