The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet

Glastras, SJ; Chen, H; Tsang, M; Teh, R; McGrath, RT; Zaky, A; Chen, J; Wong, MG; Pollock, CA; Saad, S

The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet

Glastras, SJ Chen, H

Tsang, M Teh, R McGrath, RT Zaky, A Chen, J Wong, MG Pollock, CA Saad, S

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Publication Type:: Journal Article
Citation:: PLoS ONE, 2017, 12 (2)
Issue Date:: 2017-02-01

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Field	Value	Language
dc.contributor.author	Glastras, SJ	en_US
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752	en_US
dc.contributor.author	Tsang, M	en_US
dc.contributor.author	Teh, R	en_US
dc.contributor.author	McGrath, RT	en_US
dc.contributor.author	Zaky, A	en_US
dc.contributor.author	Chen, J	en_US
dc.contributor.author	Wong, MG	en_US
dc.contributor.author	Pollock, CA	en_US
dc.contributor.author	Saad, S https://orcid.org/0000-0001-8067-8046	en_US
dc.date.available	2017-02-07	en_US
dc.date.issued	2017-02-01	en_US
dc.identifier.citation	PLoS ONE, 2017, 12 (2)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/83334
dc.description.abstract	© 2017 Glastras et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Aims/Hypothesis: Developmental programming induced by maternal obesity influences the development of chronic disease in offspring. In the present study, we aimed to determine whether maternal obesity exaggerates obesity-related kidney disease. Methods: Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow or HFD. At postnatal Week 8, HFD-fed offspring were administered one dose streptozotocin (STZ, 100 mg/kg i.p.) or vehicle control. Metabolic parameters and renal functional and structural changes were observed at postnatal Week 32. Results: HFD-fed offspring had increased adiposity, glucose intolerance and hyperlipidaemia, associated with increased albuminuria and serum creatinine levels. Their kidneys displayed structural changes with increased levels of fibrotic, inflammatory and oxidative stress markers. STZ administration did not potentiate the renal effects of HFD. Though maternal obesity had a sustained effect on serum creatinine and oxidative stress markers in lean offspring, the renal consequences of maternal obesity were overwhelmed by the powerful effect of diet-induced obesity. Conclusion: Maternal obesity portends significant risks for metabolic and renal health in adult offspring. However, diet-induced obesity is an overwhelming and potent stimulus for the development of CKD that is not potentiated by maternal obesity.	en_US
dc.relation.ispartof	PLoS ONE	en_US
dc.relation.isbasedon	10.1371/journal.pone.0172644	en_US
dc.subject.classification	General Science & Technology	en_US
dc.subject.mesh	Kidney	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice, Inbred C57BL	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Prenatal Exposure Delayed Effects	en_US
dc.subject.mesh	Glucose Intolerance	en_US
dc.subject.mesh	Obesity	en_US
dc.subject.mesh	Fibrosis	en_US
dc.subject.mesh	Creatinine	en_US
dc.subject.mesh	Oxidative Stress	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Adiposity	en_US
dc.subject.mesh	Maternal Nutritional Physiological Phenomena	en_US
dc.subject.mesh	Diet, High-Fat	en_US
dc.subject.mesh	Biomarkers	en_US
dc.title	The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	12	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	12	en_US

Abstract:

© 2017 Glastras et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Aims/Hypothesis: Developmental programming induced by maternal obesity influences the development of chronic disease in offspring. In the present study, we aimed to determine whether maternal obesity exaggerates obesity-related kidney disease. Methods: Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow or HFD. At postnatal Week 8, HFD-fed offspring were administered one dose streptozotocin (STZ, 100 mg/kg i.p.) or vehicle control. Metabolic parameters and renal functional and structural changes were observed at postnatal Week 32. Results: HFD-fed offspring had increased adiposity, glucose intolerance and hyperlipidaemia, associated with increased albuminuria and serum creatinine levels. Their kidneys displayed structural changes with increased levels of fibrotic, inflammatory and oxidative stress markers. STZ administration did not potentiate the renal effects of HFD. Though maternal obesity had a sustained effect on serum creatinine and oxidative stress markers in lean offspring, the renal consequences of maternal obesity were overwhelmed by the powerful effect of diet-induced obesity. Conclusion: Maternal obesity portends significant risks for metabolic and renal health in adult offspring. However, diet-induced obesity is an overwhelming and potent stimulus for the development of CKD that is not potentiated by maternal obesity.

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http://hdl.handle.net/10453/83334