Phytochemical and Larvicidal Studies on Stemona curtisii: Structure of a New Pyrido[1,2-a]azepine Stemona Alkaloid
Mungkornasawakul, P
Pyne, SG
Jatisatienr, A
Supyen, D
Jatisatienr, C
Lie, W
Ung, AT
Skelton, BW
White, AH
- Publication Type:
- Journal Article
- Citation:
- Journal of Natural Products, 2004, 67 (4), pp. 675 - 677
- Issue Date:
- 2004-04-01
Closed Access
Filename | Description | Size | |||
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2008005055OK.pdf | 121.67 kB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Mungkornasawakul, P | en_US |
dc.contributor.author | Pyne, SG | en_US |
dc.contributor.author | Jatisatienr, A | en_US |
dc.contributor.author | Supyen, D | en_US |
dc.contributor.author | Jatisatienr, C | en_US |
dc.contributor.author | Lie, W | en_US |
dc.contributor.author |
Ung, AT https://orcid.org/0000-0002-5665-0702 |
en_US |
dc.contributor.author | Skelton, BW | en_US |
dc.contributor.author | White, AH | en_US |
dc.date.issued | 2004-04-01 | en_US |
dc.identifier.citation | Journal of Natural Products, 2004, 67 (4), pp. 675 - 677 | en_US |
dc.identifier.issn | 0163-3864 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/8701 | |
dc.description.abstract | A new pentacyclic Stemona alkaloid, stemocurtisinol (3), with a pyrido[1,2-α]azepine A,B-ring system, and the known pyrrolo[1,2-α ]azepine alkaloid oxyprotostemonine (4) have been isolated from a root extract of S. curtisii. The structure and relative stereochemistry of stemocurtisinol was determined by spectral data interpretation and X-ray crystallography. This compound is a diastereoisomer of oxystemokerrin and has the opposite configuration at C-4 and C-19. The individual alkaloid components showed significant larvicidal activity (IC50 4-39 ppm) on mosquito larvae (Anopheles minimus HO). | en_US |
dc.relation.ispartof | Journal of Natural Products | en_US |
dc.relation.isbasedon | 10.1021/np034066u | en_US |
dc.subject.classification | Medicinal & Biomolecular Chemistry | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anopheles | en_US |
dc.subject.mesh | Stemonaceae | en_US |
dc.subject.mesh | Alkaloids | en_US |
dc.subject.mesh | Azepines | en_US |
dc.subject.mesh | Furans | en_US |
dc.subject.mesh | Crystallography, X-Ray | en_US |
dc.subject.mesh | Inhibitory Concentration 50 | en_US |
dc.subject.mesh | Molecular Structure | en_US |
dc.subject.mesh | Larva | en_US |
dc.subject.mesh | Thailand | en_US |
dc.title | Phytochemical and Larvicidal Studies on Stemona curtisii: Structure of a New Pyrido[1,2-a]azepine Stemona Alkaloid | en_US |
dc.type | Journal Article | |
utslib.citation.volume | 4 | en_US |
utslib.citation.volume | 67 | en_US |
utslib.for | 0601 Biochemistry and Cell Biology | en_US |
utslib.for | 03 Chemical Sciences | en_US |
utslib.for | 06 Biological Sciences | en_US |
utslib.for | 11 Medical and Health Sciences | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences | |
pubs.organisational-group | /University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology | |
utslib.copyright.status | closed_access | |
pubs.issue | 4 | en_US |
pubs.publication-status | Published | en_US |
pubs.volume | 67 | en_US |
Abstract:
A new pentacyclic Stemona alkaloid, stemocurtisinol (3), with a pyrido[1,2-α]azepine A,B-ring system, and the known pyrrolo[1,2-α ]azepine alkaloid oxyprotostemonine (4) have been isolated from a root extract of S. curtisii. The structure and relative stereochemistry of stemocurtisinol was determined by spectral data interpretation and X-ray crystallography. This compound is a diastereoisomer of oxystemokerrin and has the opposite configuration at C-4 and C-19. The individual alkaloid components showed significant larvicidal activity (IC50 4-39 ppm) on mosquito larvae (Anopheles minimus HO).
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