Phytochemical and Larvicidal Studies on Stemona curtisii: Structure of a New Pyrido[1,2-a]azepine Stemona Alkaloid
- Publication Type:
- Journal Article
- Journal of Natural Products, 2004, 67 (4), pp. 675 - 677
- Issue Date:
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
A new pentacyclic Stemona alkaloid, stemocurtisinol (3), with a pyrido[1,2-α]azepine A,B-ring system, and the known pyrrolo[1,2-α ]azepine alkaloid oxyprotostemonine (4) have been isolated from a root extract of S. curtisii. The structure and relative stereochemistry of stemocurtisinol was determined by spectral data interpretation and X-ray crystallography. This compound is a diastereoisomer of oxystemokerrin and has the opposite configuration at C-4 and C-19. The individual alkaloid components showed significant larvicidal activity (IC50 4-39 ppm) on mosquito larvae (Anopheles minimus HO).
Please use this identifier to cite or link to this item: